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Muscarinic receptor subtypes and smooth muscle function.
Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
Urinary bladder smooth muscle is enriched with muscarinic receptors, the majority of which are of the M2 subtype whereas the remaining minority belong to the M3 subtype. The objective of the presentExpand
Muscarinic receptors in the bladder: from basic research to therapeutics
  • S. Hegde
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1 February 2006
Muscarinic receptor antagonists (antimuscarinics) serve as the cornerstone in the pharmacological management of overactive bladder (OAB) by relieving the symptoms of urgency, frequency andExpand
Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria
ABSTRACT Telavancin (TD-6424) is a novel lipoglycopeptide that produces rapid and concentration-dependent killing of clinically relevant gram-positive organisms in vitro. The present studiesExpand
Peripheral 5‐HT4 receptors
  • S. Hegde, R. Eglen
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 1 October 1996
The 5‐HT4 receptor is a member of the seven transmembrane spanning G‐protein‐cou‐pled family of receptors. The receptor is positively coupled to adenylate cyclase and exists in two iso‐forms (5‐HT4SExpand
Catecholamine modulatory effects of nepicastat (RS‐25560‐197), a novel, potent and selective inhibitor of dopamine‐β‐hydroxylase
1 Inhibitory modulation of sympathetic nerve function may have a favourable impact on the progression of congestive heart failure. Nepicastat is a novel inhibitor of dopamine‐β‐hydroxylase, theExpand
Muscarinic receptor ligands and their therapeutic potential.
Over the past year, the introduction of novel ligands has accelerated the classification of muscarinic receptor subtypes and has led to a better understanding of their physiological role. ImportantExpand
Pharmacological characterization of RS 25259‐197, a novel and selective 5‐HT3 receptor antagonist, in vivo
1 The pharmacological effects in vivo, of RS 25259‐197, a selective 5‐HT3 receptor antagonist, have been investigated. 2 In anaesthetized rats, RS 25259‐197, administered by the intravenous,Expand
Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA).
Combinations of a muscarinic receptor antagonist (MA) and a β(2)-adrenoceptor agonist (BA) improve bronchodilation in COPD patients to a greater extent than drugs with either mechanism alone. Here,Expand
Efficacy of Telavancin (TD-6424), a Rapidly Bactericidal Lipoglycopeptide with Multiple Mechanisms of Action, in a Murine Model of Pneumonia Induced by Methicillin-Resistant Staphylococcus aureus
ABSTRACT The efficacy of telavancin, a bactericidal lipoglycopeptide, was compared to that of vancomycin and linezolid against methicillin-resistant Staphylococcus aureus (MRSA) in a murine pneumoniaExpand