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TAT 59

Known as: Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-(4-(1-methylethyl)phenyl)-1-butenyl)-, dihydrogen phosphate (ester), (E)-, TAT-59 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Antineoplastic AgentsEstrogen AntagonistsTamoxifen
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Novel iontophoretic administration method for local therapy of breast cancer.
2004
2004
Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma
TAT-59 suppressed the growth fo DMBA-induced mammary tumors in rats earlier and more strongly than tamoxifen (TAM). After oral… 
2004
2004
A new triphenylethylene derivative, TAT-59; hormone receptors; insulin-like growth factor 1; and growth suppression of hormone-dependent MCF-7 tumors in athymic mice
TAT-59 {(E)-4-[1-[4-[2-(dimethylamino)ethoxy]-phenyl]-2-(4-isopropyl)phenyl-1-butenyl]-phenyl-monophosphate} treatment was… 
2000
2000
Estrogen agonistic/antagonistic effects of miproxifene phosphate (TAT-59)
Purpose: We evaluated miproxifene phosphate (TAT-59) to elucidate its efficacy in antiestrogen therapy for breast cancer patients… 
1998
1998
[Late phase II study of TAT-59 (miproxifene phospate) in advanced or recurrent breast cancer patients (a double-blind comparative study with tamoxifen citrate)].
The efficacy and safety of TAT-59 (miproxifene phospate) were compared with tamoxifen citrate (TAM) in ER-positive or ER-unknown… 
1998
1998
[Phase I study of TAT-59 (a new antiestrogen) in breast cancer. TAT-59 Study Group].
Phase I study of TAT-59 (Miproxifen), an antiestrogen developed in Japan for breast cancer, was conducted with the collaboration… 
1997
1997
Antiestrogenic activity of DP-TAT-59, an active metabolite of TAT-59 against human breast cancer
Abstract Purpose: The purpose of this study was to clarify the mechanism(s) of antiestrogenic action of DP-TAT-59 ((Z)-2-(4-(1-(4… 
1996
1996
Effects of grinding and tableting on physicochemical stability of an anticancer drug, TAT-59.
The effects of grinding and tableting on the physicochemical stability of TAT-59, (E)-4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2… 
1994
1994
Effects of compression pressure on physical and chemical stability of tablets containing an anticancer drug TAT-59.
(E)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropyl) phenyl]-1-butenyl]phenyl monophosphate (TAT-59) is a new drug for… 
1993
1993
Effects of tamoxifen and the derivative (TAT) on cell cycle of MCF-7 in vitro.
The growth inhibitory activity and influences on cell-cycle progression of tamoxifen (TAM) and its derivatives [toremifene(NK… 
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