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TAPBP gene

Known as: TAPASIN, TAPA, TAP-BINDING PROTEIN 
This gene is involved in antigen presentation.
National Institutes of Health

Related topics

Related topics

5 relations
Antigen PresentationLigand BindingTAPBP protein, humanTAPBP wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Structural Mechanism of ER Retrieval of MHC Class I by Cowpox
Structure-function studies reveal how a poxvirus protein blocks cell surface display of MHC class I by exploiting cellular ER… 
Highly Cited
2009
Highly Cited
2009
Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange
The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high‐affinity peptides onto MHC class I molecules… 
Highly Cited
2008
Highly Cited
2008
Differential tapasin dependence of MHC class I molecules correlates with conformational changes upon peptide dissociation: a molecular dynamics simulation study.
2003
2003
Characterization of the ERp57-Tapasin complex by rapid cellular acidification and thiol modification.
Major histocompatibility complex (MHC) class I molecules bind and present short peptides to cells of the immune system. The… 
2001
2001
Functional Roles of TAP and Tapasin in the Assembly of M3-N-Formylated Peptide Complexes1
H2-M3 is a MHC class Ib molecule with a high propensity to bind N-formylated peptides. Due to the paucity of endogenous Ag, the… 
Highly Cited
2001
Highly Cited
2001
Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines.
Human tumor cells frequently exhibit abnormalities in the major histocompatibility complex (MHC) class I surface expression which… 
2001
2001
Tapasin Enhances Peptide-Induced Expression of H2-M3 Molecules, but Is Not Required for the Retention of Open Conformers1
H2-M3 is a class Ib MHC molecule that binds a highly restricted pool of peptides, resulting in its intracellular retention under… 
1999
1999
Tapasin Enhances Assembly of Transporters Associated with Antigen Processing-dependent and -independent Peptides with HLA-A2 and HLA-B27 Expressed in Insect Cells*
Assembly of HLA class I-peptide complexes is assisted by multiple proteins that associate with HLA molecules in loading complexes… 
1998
1998
Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain
The present study defines the expression pattern of TAPA (target of the antiproliferative antibody, also known as CD81) in the… 
1997
1997
Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2
Prior to loading antigenic peptides, assembled major histocompatibility complex (MHC) class I molecules associate with the… 
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