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Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity
Human cytomegalovirus uses a host-encoded antiviral protein to its own advantage. Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV)Expand
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Viperin: a multifunctional, interferon-inducible protein that regulates virus replication.
Viperin is an interferon-inducible protein that inhibits the replication of a variety of viruses by apparently diverse mechanisms. In some circumstances, it also plays a role in intracellularExpand
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Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study.
Major histocompatibility (MHC) Class II cell surface proteins present antigenic peptides to the immune system. Class II structures in complex with peptides but not in the absence of peptide areExpand
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Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange
The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high‐affinity peptides onto MHC class I molecules. It mediates peptide editing, i.e. the binding of peptides ofExpand
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Peptide binding to MHC class I and II proteins: new avenues from new methods.
Major histocompatibility complex (MHC) class I and II proteins have been in the focus of interest for immunologists, biochemists, cell biologists, and structural biologists for decades. With dozensExpand
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The continuously increasing amount of funds which the healthcare requires put in front of the healthcare officers the problem for a more efficient economic distribution and spending of the healthcareExpand