M. Zacharias

Publications236
h-index42
Citations5,525
Highly Influential Citations221
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A family of macrodomain proteins reverses cellular mono-ADP-ribosylation
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD+ to transfer either single or multiple… Expand
  • 196
  • 16
EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results
BackgroundAccurate prediction of antigenic epitopes is important for immunologic research and medical applications, but it is still an open problem in bioinformatics. The case for discontinuous… Expand
  • 102
  • 16
Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach
The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. In nonlenticular cells, it… Expand
  • 116
  • 14
Prediction of antigenic epitopes on protein surfaces by consensus scoring
BackgroundPrediction of antigenic epitopes on protein surfaces is important for vaccine design. Most existing epitope prediction methods focus on protein sequences to predict continuous epitopes… Expand
  • 83
  • 12
Protein-protein docking with a reduced protein model accounting for side-chain flexibility.
  • M. Zacharias
  • Chemistry, Medicine
  • Protein science : a publication of the Protein…
  • 1 June 2003
A protein-protein docking approach has been developed based on a reduced protein representation with up to three pseudo atoms per amino acid residue. Docking is performed by energy minimization in… Expand
  • 277
  • 11
Tapasin and other chaperones: models of the MHC class I loading complex
Abstract MHC (major histocompatibility complex) class I molecules bind intracellular virus-derived peptides in the endoplasmic reticulum (ER) and present them at the cell surface to cytotoxic T… Expand
  • 87
  • 9
Effective Dephosphorylation of Src Substrates by SHP-1*
The protein-tyrosine phosphatase SHP-1 is a negative regulator of multiple signal transduction pathways. We observed that SHP-1 effectively antagonized Src-dependent phosphorylations in HEK293 cells.… Expand
  • 96
  • 7
Conformational flexibility of the MHC class I alpha1-alpha2 domain in peptide bound and free states: a molecular dynamics simulation study.
Major histocompatibility complex class I proteins play a key role in the recognition and presentation of peptide antigens to the host immune system. The structure of various major histocompatibility… Expand
  • 45
  • 7
A statistical analysis of random mutagenesis methods used for directed protein evolution.
We have developed a statistical method named MAP (mutagenesis assistant program) to equip protein engineers with a tool to develop promising directed evolution strategies by comparing 19 mutagenesis… Expand
  • 136
  • 6
Community-wide assessment of protein-interface modeling suggests improvements to design methodology.
The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment of protein Structure Prediction) experiments have demonstrated the power of community-wide tests of methodology… Expand
  • 125
  • 5