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- Publications
- Influence
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation
- G. Jankevicius, M. Hassler, +4 authors A. Ladurner
- Chemistry, Medicine
- Nature Structural &Molecular Biology
- 10 March 2013
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD+ to transfer either single or multiple… Expand
EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results
- S. Liang, Dandan Zheng, D. Standley, B. Yao, M. Zacharias, C. Zhang
- Computer Science, Medicine
- BMC Bioinformatics
- 16 July 2010
TLDR
Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach
- N. Braun, M. Zacharias, +7 authors S. Weinkauf
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 5 December 2011
The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. In nonlenticular cells, it… Expand
Prediction of antigenic epitopes on protein surfaces by consensus scoring
- S. Liang, Dandan Zheng, C. Zhang, M. Zacharias
- Medicine, Biology
- BMC Bioinformatics
- 22 September 2009
TLDR
Protein–protein docking with a reduced protein model accounting for side‐chain flexibility
- M. Zacharias
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 June 2003
A protein–protein docking approach has been developed based on a reduced protein representation with up to three pseudo atoms per amino acid residue. Docking is performed by energy minimization in… Expand
Tapasin and other chaperones: models of the MHC class I loading complex
- Cynthia Anne Wright, Patrycja Kozik, M. Zacharias, S. Springer
- Biology, Medicine
- Biological chemistry
- 2004
Abstract MHC (major histocompatibility complex) class I molecules bind intracellular virus-derived peptides in the endoplasmic reticulum (ER) and present them at the cell surface to cytotoxic T… Expand
Conformational flexibility of the MHC class I alpha1-alpha2 domain in peptide bound and free states: a molecular dynamics simulation study.
- M. Zacharias, S. Springer
- Medicine
- Biophysical journal
- 2004
Major histocompatibility complex class I proteins play a key role in the recognition and presentation of peptide antigens to the host immune system. The structure of various major histocompatibility… Expand
Effective Dephosphorylation of Src Substrates by SHP-1*
- C. Frank, C. Burkhardt, +5 authors Frank-D. Böhmer
- Chemistry, Medicine
- Journal of Biological Chemistry
- 19 March 2004
The protein-tyrosine phosphatase SHP-1 is a negative regulator of multiple signal transduction pathways. We observed that SHP-1 effectively antagonized Src-dependent phosphorylations in HEK293 cells.… Expand
A statistical analysis of random mutagenesis methods used for directed protein evolution.
- T. S. Wong, D. Roccatano, M. Zacharias, U. Schwaneberg
- Biology, Medicine
- Journal of molecular biology
- 27 January 2006
We have developed a statistical method named MAP (mutagenesis assistant program) to equip protein engineers with a tool to develop promising directed evolution strategies by comparing 19 mutagenesis… Expand
Binding site prediction and improved scoring during flexible protein–protein docking with ATTRACT
- S. Fiorucci, M. Zacharias
- Chemistry, Medicine
- Proteins
- 15 November 2010
The ATTRACT protein–protein docking program combined with a coarse‐grained protein model has been used to predict protein–protein complex structures in CAPRI rounds 13–19. For six targets acceptable… Expand