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TAPBP protein, human

Known as: TAP-associated protein, human, TPN, TAP-Associated Protein 
Tapasin (448 aa, ~48 kDa) is encoded by the human TAPBP gene. This protein is involved in activity of the MHC class I peptide-loading complex.
National Institutes of Health

Related topics

Related topics

10 relations
Antigen PresentationIntegral Membrane ProteinsLigand BindingSmooth endoplasmic reticulum membrane

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Preferential interaction of MHC class I with TAPBPR in the absence of glycosylation
Review
2010
Review
2010
Time synchronization in wireless sensor networks: A survey
Wireless sensor networks consist of small devices distributed over geographical area. Each one of these devices has sensing… 
Highly Cited
2009
Highly Cited
2009
Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange
The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high‐affinity peptides onto MHC class I molecules… 
2003
2003
Characterization of the ERp57-Tapasin complex by rapid cellular acidification and thiol modification.
Major histocompatibility complex (MHC) class I molecules bind and present short peptides to cells of the immune system. The… 
2001
2001
Functional Roles of TAP and Tapasin in the Assembly of M3-N-Formylated Peptide Complexes1
H2-M3 is a MHC class Ib molecule with a high propensity to bind N-formylated peptides. Due to the paucity of endogenous Ag, the… 
Highly Cited
2001
Highly Cited
2001
Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines.
Human tumor cells frequently exhibit abnormalities in the major histocompatibility complex (MHC) class I surface expression which… 
2001
2001
Tapasin Enhances Peptide-Induced Expression of H2-M3 Molecules, but Is Not Required for the Retention of Open Conformers1
H2-M3 is a class Ib MHC molecule that binds a highly restricted pool of peptides, resulting in its intracellular retention under… 
1999
1999
Tapasin Enhances Assembly of Transporters Associated with Antigen Processing-dependent and -independent Peptides with HLA-A2 and HLA-B27 Expressed in Insect Cells*
Assembly of HLA class I-peptide complexes is assisted by multiple proteins that associate with HLA molecules in loading complexes… 
Review
1999
Review
1999
The role of tapasin in MHC class I antigen assembly
The discovery of tapasin has shed new light on the mechanisms of major histocompatibility complex (MHC) class I assembly in the… 
1997
1997
Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2
Prior to loading antigenic peptides, assembled major histocompatibility complex (MHC) class I molecules associate with the… 
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