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TAPBP protein, human

Known as: TAP-associated protein, human, TPN, TAP-Associated Protein 
Tapasin (448 aa, ~48 kDa) is encoded by the human TAPBP gene. This protein is involved in activity of the MHC class I peptide-loading complex.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Tapasin is a glycoprotein critical for loading major histocompatibility complex (MHC) class I molecules with high-affinity… Expand
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Review
2008
Review
2008
The assembly of major histocompatibility complex (MHC) class I molecules is one of the more widely studied examples of protein… Expand
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Highly Cited
2007
Highly Cited
2007
Major histocompatibility complex (MHC) class I glycoproteins bind peptides in the endoplasmic reticulum after incorporation into… Expand
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Highly Cited
2007
Highly Cited
2007
HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of… Expand
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Highly Cited
2003
Highly Cited
2003
Conventionally, MHC class I-restricted antigen (Ag) processing requires the action of the multimolecular peptide-loading complex… Expand
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Highly Cited
2002
Highly Cited
2002
The class I protein HLA-B27 confers susceptibility to inflammatory arthritis in humans and when overexpressed in rodents for… Expand
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Highly Cited
2002
Highly Cited
2002
The presence of a disulfide bond inside the peptide binding groove of MHC class I molecules and of the thiol oxidoreductase ERp57… Expand
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Highly Cited
1998
Highly Cited
1998
Tapasin forms a bridge between TAP (transporters associated with antigen processing) and MHC class I molecules and plays a… Expand
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Highly Cited
1998
Highly Cited
1998
Tapasin is a resident ER protein believed to be critical for antigen presentation by HLA class I molecules. We demonstrate that… Expand
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Highly Cited
1997
Highly Cited
1997
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone… Expand
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