TAPBP protein, human

Known as: TAP-associated protein, human, TPN, TAP-Associated Protein 
Tapasin (448 aa, ~48 kDa) is encoded by the human TAPBP gene. This protein is involved in activity of the MHC class I peptide-loading complex.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
05101519652017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Tapasin is a glycoprotein critical for loading major histocompatibility complex (MHC) class I molecules with high-affinity… (More)
  • table 1
  • figure 1
  • figure 3
  • table 2
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Major histocompatibility complex (MHC) class I glycoproteins bind peptides in the endoplasmic reticulum after incorporation into… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Induction of cytotoxic T-cell immunity requires the phagocytosis of pathogens, virus-infected or dead tumour cells by dendritic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The class I protein HLA-B27 confers susceptibility to inflammatory arthritis in humans and when overexpressed in rodents for… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The presence of a disulfide bond inside the peptide binding groove of MHC class I molecules and of the thiol oxidoreductase ERp57… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Tapasin mediates the binding of MHC class I molecules to the transporter associated with antigen processing (TAP). Deletion… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Viral strategies for immune evasion include inhibition of various steps in the class I MHC assembly pathway. Here, we demonstrate… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
1999
1999
Presentation of antigen-derived peptides by major histocompatibility complex (MHC) class I molecules is dependent on an… (More)
  • table I
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Tapasin forms a bridge between TAP (transporters associated with antigen processing) and MHC class I molecules and plays a… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone… (More)
Is this relevant?