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T-Cell Leukemia Homeobox Protein 3

Known as: Homeobox Protein Hox-11L2, TLX3 
T-cell leukemia homeobox protein 3 (291 aa, ~32 kDa) is encoded by the human TLX3 gene. This protein may be involved in transcriptional modulation.
National Institutes of Health

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7 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsTLX3 gene

Papers overview

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2018
2018
Dynamic changes in DNA methylation patterns in canine lymphoma cell lines demonstrated by genome-wide quantitative DNA methylation analysis.
2018
2018
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia
2014
2014
Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia
While survival from childhood acute lymphoblastic leukemia (ALL) has improved significantly over the past three decades… 
2013
2013
Linking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia.
2012
2012
Tlx3 and Runx1 Act in Combination to Coordinate the Development of a Cohort of Nociceptors, Thermoceptors, and Pruriceptors
Neurons in the mouse dorsal root ganglia (DRGs) are composed of a variety of sensory modalities, such as pain-related nociceptors… 
2011
2011
Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer.
The development of resistance to cisplatin during treatment of bladder cancer constitutes a major obstacle to curing bladder… 
2010
2010
Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults
Background Molecular lesions in T-cell acute lymphoblastic leukemias affect regulators of cell cycle, proliferation… 
2009
2009
WT 1 mutations in TALL
Valeria Tosello,1 Marc R. Mansour,2 Kelly Barnes,1 Maddalena Paganin,3 Maria Luisa Sulis,1,4 Sarah Jenkinson,2 Christopher G… 
2008
2008
Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia
We describe four cases of childhood B-cell progenitor acute lymphoblastic leukaemia (BCP-ALL) and one of T-cell (T-ALL) with… 
2006
2006
Nuclear Factor Y Drives Basal Transcription of the Human TLX3, a Gene Overexpressed in T-Cell Acute Lymphocytic Leukemia
Based on a knocked-out mouse model and a few expression studies, TLX3 is regarded as a homeobox gene crucial for the development… 
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