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MicroRNA expression profiles classify human cancers
A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours. Expand
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling. Expand
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated. Expand
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Findings identify transcriptional control of PTEN and regulation of the PI3K-AKT pathway as key elements of the leukemogenic program activated by NOTCH1 and provide the basis for the design of new therapeutic strategies for T-ALL. Expand
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
It is shown that five different T cell oncogenes are often aberrantly expressed in the absence of chromosomal abnormalities, and HOX11L2 activation is identified as a novel event in T cell leukemogenesis. Expand
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
  • T. Palomero, Wei Keat Lim, +14 authors A. Ferrando
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 28 November 2006
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis overExpand
Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC
Results are presented from searches for the standard model Higgs boson in proton-proton collisions at sqrt(s)=7 and 8 TeV in the CMS experiment at the LHC, using data samples corresponding toExpand
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
It is indicated that aberrant PI3K pathway signaling is strongly associated with metastasis and poor survival across carcinoma types, highlighting the enormous potential impact on patient survival that pathway inhibition could achieve. Expand
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
The data suggest that FBW7 is a novel tumor suppressor in T cell leukemia, and implicate the loss ofFBW7 function as a potential mechanism of drug resistance in T-ALL. Expand
Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
It is found that cyclin D3(-/-) animals fail to undergo normal expansion of immature T lymphocytes and show greatly reduced susceptibility to T cell malignancies triggered by specific oncogenic pathways. Expand