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MicroRNA expression profiles classify human cancers
Recent work has revealed the existence of a class of small non-coding RNA species, known as microRNAs (miRNAs), which have critical functions across various biological processes. Here we use a new,Expand
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cellExpand
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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not beenExpand
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a promising target for drugs such as γ-secretase inhibitors, which blockExpand
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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor genes. Here we show that five different T cell oncogenes (HOX11, TAL1,Expand
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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable testExpand
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Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC
Results are presented from searches for the standard model Higgs boson in proton-proton collisions at sqrt(s)=7 and 8 TeV in the CMS experiment at the LHC, using data samples corresponding toExpand
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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations truncate its C-terminalExpand
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Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
The D-type cyclins (cyclins D1, D2, and D3) are components of the core cell cycle machinery in mammalian cells. Cyclin D3 gene is rearranged and the protein is overexpressed in several human lymphoidExpand
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Myc-Induced T Cell Leukemia in Transgenic Zebrafish
The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility. Here we describe the induction of clonally derived T cell acute lymphoblasticExpand
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