Linking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia.

@article{Starza2013LinkingGL,
  title={Linking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia.},
  author={Roberta La Starza and Antonella Lettieri and Valentina Pierini and Valeria Nofrini and Paolo Gorello and Simona Songia and Barbara Crescenzi and Geertruy Te Kronnie and Marco Giordan and Anna Leszl and Maria Grazia Valsecchi and Franco Aversa and Giuseppe Basso and Andrea Biondi and Valentino Conter and Giovanni Cazzaniga and Cristina Mecucci},
  journal={Leukemia research},
  year={2013},
  volume={37 8},
  pages={928-35}
}
Multiple lesions in genes that are involved in cell cycle control, proliferation, survival and differentiation underlie T-cell acute lymphoblastic leukaemia (T-ALL). We translated these biological insights into clinical practice to improve diagnostic work-ups and patient management. Combined interphase fluorescence in situ hybridization (CI-FISH), single nucleotide polymorphism (SNP), and gene expression profiles (GEP) were applied in 51 children with T-ALL who were stratified according to… CONTINUE READING