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T 30177

Known as: T30177, T-30177, AR 177 
National Institutes of Health

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Related topics

2 relations
AR177

Broader (1)

Oligonucleotides

Papers overview

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Highly Cited
2010
Highly Cited
2010
Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir.
Resistance to raltegravir (RAL), the first HIV-1 integrase (IN) inhibitor approved by the FDA, involves three genetic pathways… 
2004
2004
Anti-HIV-1 activity and mode of action of mirror image oligodeoxynucleotide analogue of Zintevir.
2000
2000
Acute, multiple-dose, and genetic toxicology of AR177, an anti-HIV oligonucleotide.
AR177 (Zintevir) is a 17-mer oligonucleotide that has been shown to have anti-HIV activity and to be a potent HIV-1 integrase… 
1999
1999
Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4.
Negatively charged albumins (NCAs) have been identified as potent inhibitors of HIV-1 replication in vitro. Time of addition… 
Review
1999
Review
1999
Oligonucleotides as inhibitors of human immunodeficiency virus.
  • A. Field
  • Current opinion in molecular therapeutics (Print)
  • 1999
  • Corpus ID: 33559561
Inhibition of human immunodeficiency virus (HIV) replication by oligonucleotides is a complex process and may be implemented by… 
Highly Cited
1998
Highly Cited
1998
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
The human immunodeficiency virus (HIV) inhibitor AR177 (T30177, Zintevir) has been identified as a potent inhibitor of HIV… 
Highly Cited
1997
Highly Cited
1997
Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.
Oligonucleotides that can form a highly stable intramolecular four-stranded DNA structure containing two stacked guanosine… 
Highly Cited
1996
Highly Cited
1996
Intramolecular G-quartet Motifs Confer Nuclease Resistance to a Potent Anti-HIV Oligonucleotide (*)
We have identified a potentially therapeutic anti-human immunodeficiency virus (HIV)-1 oligonucleotide composed entirely of… 
1996
1996
The first integrase inhibitor.
Clinical trials of an HIV integrase inhibitor, Aronex Pharmaceuticals' AR-177, are in progress at San Francisco General… 
Highly Cited
1995
Highly Cited
1995
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1
T30177, an oligonucleotide composed of only deoxyguanosine and thymidine, is 17 nucleotides in length and contains single… 
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