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Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.*
Data suggest that GRFT is a new type of lectin that binds to various viral glycoproteins in a monosaccharide-dependent manner and could be a potential candidate microbicide to prevent the sexual transmission of HIV and AIDS. Expand
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development
The novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), is isolated and sequenced from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum and is highly resistant to physicochemical denaturation, further enhancing its potential as an anti-HIV microbicide. Expand
Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS
Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity. Expand
Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion.
The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained allExpand
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Calanolide A was active not only against the AZT-resistant G-9106 strain of HIV-1 but also against the pyridinone-resistant A17 strain, which was of particular interest since the A17 virus is highly resistant to previously known HIV- 1 specific, non-nucleoside RT inhibitors. Expand
Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1
Shikonin, as a naturally occurring, low-molecular-weight pan-chemokine receptor inhibitor, constitutes a basis for the development of novel anti-HIV therapeutic agents. Expand
A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.
A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein displayed potent anticytopathic activity against laboratory strainsExpand
Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles.
It is shown that NM domains appear to be remnants generated by the internalization of small GJ channel clusters that bud over time from central plaque areas, which may have implications for the process of endocytic vesicle budding and how the known dynamic channel replenishment of functional GJ plaques can be achieved. Expand
In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials.
The results show that this "universal" placebo has adequate physical properties, is sufficiently stable as a vaginal gel formulation, and is safe and sufficiently inactive for use in the clinical study of investigational microbicides. Expand