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Synthetic Genes

Known as: Artificial Genes, Synthetic Gene, Genes, Artificial 
Biologically functional sequences of DNA chemically synthesized in vitro.
National Institutes of Health

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aspects of radiation effectsphysiological aspectssynthetic construct

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chameleon alpha protein, synthetic

Papers overview

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Highly Cited
2016
Highly Cited
2016
Spliced synthetic genes as internal controls in RNA sequencing experiments
RNA sequencing (RNA-seq) can be used to assemble spliced isoforms, quantify expressed genes and provide a global profile of the… 
Review
2014
Review
2014
Computational Tools and Algorithms for Designing Customized Synthetic Genes
Advances in DNA synthesis have enabled the construction of artificial genes, gene circuits, and genomes of bacterial scale… 
Highly Cited
2014
Highly Cited
2014
Engineering large viral DNA genomes using the CRISPR‐Cas9 system
Manipulation of viral genomes is essential for studying viral gene function and utilizing viruses for therapy. Several techniques… 
Review
2011
Review
2011
Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy
In this paper, we discuss the challenge of large‐scale quantification of a proteome, referring to our programme that aims to… 
Highly Cited
2010
Highly Cited
2010
Multifactorial determinants of protein expression in prokaryotic open reading frames.
Highly Cited
2009
Highly Cited
2009
Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus.
Highly Cited
2005
Highly Cited
2005
Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) is a difficult target for vaccine development, in part because of its ever… 
Highly Cited
2000
Highly Cited
2000
Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides.
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… 
Highly Cited
1994
Highly Cited
1994
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
A chimeric protein capable of binding and neutralizing tumor necrosis factor (TNF) and lymphotoxin was expressed in mice… 
Highly Cited
1994
Highly Cited
1994
Recombinant immunoglobulin variable domains generated from synthetic genes provide a system for in vitro characterization of light‐chain amyloid proteins
The primary structural features that render human monoclonal light chains amyloidogenic are presently unknown. To gain further… 
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