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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
Nat. Neurosci. 6, 21–27 (2003) During revision, panels were inadvertently exchanged in two figures. In Fig. 4, the panel labeled d should have been e and vice versa. In Fig. 5, the panel labeled bExpand
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A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
Efficient retrograde access to projection neurons for the delivery of sensors and effectors constitutes an important and enabling capability for neural circuit dissection. Such an approach would alsoExpand
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Substrate modulus directs neural stem cell behavior.
Although biochemical signals that modulate stem cell self-renewal and differentiation were extensively studied, only recently were the mechanical properties of a stem cell's microenvironment shown toExpand
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Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
HIV-1 Tat transactivation is vital for completion of the viral life cycle and has been implicated in determining proviral latency. We present an extensive experimental/computational study of an HIV-1Expand
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PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation
The phosphoinositide 3‐OH kinase (PI3K)/Akt pathway has been implicated in regulating several important cellular processes, including apoptosis, survival, proliferation, and metabolism. Using bothExpand
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In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous
Injection of a new gene therapy vector into the easily accessible vitreous transduced the entire retina and rescued disease phenotypes. New Eye Pod Gene therapy mediated by adeno-associated virusExpand
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The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells.
There has been an increasing interest in understanding how the mechanical properties of the microenvironment influence stem cell fate. We describe studies of the proliferation and differentiation ofExpand
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Optogenetic protein clustering and signaling activation in mammalian cells
We report an optogenetic method based on Arabidopsis thaliana cryptochrome 2 for rapid and reversible protein oligomerization in response to blue light. We demonstrated its utility by photoactivatingExpand
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Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses
Muscle stem (satellite) cells are relatively resistant to cell‐autonomous aging. Instead, their endogenous signaling profile and regenerative capacity is strongly influenced by the aged P‐Smad3,Expand
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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
Neural stem cells exist in the developing and adult nervous systems of all mammals, but the basic mechanisms that control their behavior are not yet well understood. Here, we investigated the role ofExpand
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