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Innate Immune Responses in House Dust Mite Allergy
Sensitizations to house dust mites (HDM) trigger strong exacerbated allergen-induced inflammation of the skin and airways mucosa from atopic subjects resulting in atopic dermatitis as well asExpand
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  • Open Access
Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22.
Dendritic cells (DC) are potent antigen - presenting cells that can orientate the immune response towards a Th1 or a Th2 type. DC produce chemokines that are involved in the recruitment of either Th1Expand
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The role of innate immunity activation in house dust mite allergy.
  • A. Jacquet
  • Medicine, Biology
  • Trends in molecular medicine
  • 1 October 2011
House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgEExpand
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Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma1
Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCsExpand
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DiC14‐amidine cationic liposomes stimulate myeloid dendritic cells through Toll‐like receptor 4
DiC14‐amidine cationic liposomes were recently shown to promote Th1 responses when mixed with allergen. To further define the mode of action of diC14‐amidine as potential vaccine adjuvant, weExpand
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Patterns of IgE sensitization in house dust mite‐allergic patients: implications for allergen immunotherapy
Understanding patterns of IgE sensitization in Dermatophagoides‐allergic patients living in various geographical areas is necessary to design a product suitable for worldwide allergen immunotherapyExpand
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Probiotic Escherichia coli Nissle 1917 activates DC and prevents house dust mite allergy through a TLR4‐dependent pathway
Experimental animal and human studies have demonstrated that probiotic strains have beneficial effects on allergy. Here we report that the probiotic Escherichia coli Nissle 1917 strain (EcN) is ableExpand
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  • Open Access
Effects of armagnac or vodka on platelet aggregation in healthy volunteers: a randomized controlled clinical trial.
BACKGROUND Cardiovascular mortality is especially low in southwest France (the French Paradox). In previous experimental studies, we found that alcohol-free extracts of armagnac could inhibit humanExpand
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Development of recombinant stable house dust mite allergen Der p 3 molecules for component‐resolved diagnosis and specific immunotherapy
The allergen Der p 3 is underrepresented in house dust mite (HDM) extracts probably due to autolysis. Recombinant stable molecule of the allergen is thus needed to improve the diagnosis of allergyExpand
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The minor house dust mite allergen Der p 13 is a fatty acid‐binding protein and an activator of a TLR2‐mediated innate immune response
The house dust mite (HDM) allergen Der p 13 could be a lipid‐binding protein able to activate key innate signaling pathways in the initiation of the allergic response. We investigated the IgEExpand
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