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Sumatriptan

Known as: 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide, Sumatriptán, 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide 
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is… Expand
Review
2018
Review
2018
BackgroundThe MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were… Expand
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Review
2017
Review
2017
Policy Points: Our study indicates that there are opportunities for cost savings in generic drug markets in Europe and the United… Expand
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Highly Cited
2009
Highly Cited
2009
Background:  Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients’ quality… Expand
Highly Cited
2004
Highly Cited
2004
For many migraine patients, triptan therapy provides complete pain relief in some attacks but not in others. Here, we tested… Expand
Highly Cited
2000
Highly Cited
2000
Objective. To compare the efficacy and tolerability of sumatriptan nasal spray (NS; 5 mg, 10 mg, and 20 mg) with placebo for the… Expand
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Highly Cited
1996
Highly Cited
1996
Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas… Expand
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Highly Cited
1995
Highly Cited
1995
Evidence from animal experiments shows that the brain stem is involved in the pathophysiology of migraine. To investigate human… Expand
Highly Cited
1993
Highly Cited
1993
Both clinical and physiological consideration of migraine suggests that the pathophysiology of the syndrome is intimately linked… Expand
Review
1992
Review
1992
  • M. Moskowitz
  • Trends in pharmacological sciences
  • 1992
  • Corpus ID: 4264125
Sumatriptan and the ergot alkaloids are useful tools for deciphering drug mechanisms in migraine and related headaches. Both… Expand