Sumatriptan

Known as: 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide, Sumatriptán, 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide 
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The purpose of the present study was to develop intranasal delivery systems of sumatriptan using thermoreversible polymer… (More)
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Highly Cited
2003
Highly Cited
2003
The placebo and nocebo effect is believed to be mediated by both cognitive and conditioning mechanisms, although little is known… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND In animals, activation of 5-HT(1) like receptors causes a relaxation of the gastric fundus through the activation of… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND & AIMS Impaired accommodation of the proximal stomach to a meal has been reported in functional dyspepsia, but its… (More)
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Highly Cited
1996
Highly Cited
1996
Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas… (More)
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Highly Cited
1995
Highly Cited
1995
Evidence from animal experiments shows that the brain stem is involved in the pathophysiology of migraine. To investigate human… (More)
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Highly Cited
1993
Highly Cited
1993
Both clinical and physiological consideration of migraine suggests that the pathophysiology of the syndrome is intimately linked… (More)
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Review
1992
Review
1992
Sumatriptan and the ergot alkaloids are useful tools for deciphering drug mechanisms in migraine and related headaches. Both… (More)
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Highly Cited
1991
Highly Cited
1991
The combination of measurements of regional cerebral blood flow (rCBF) and blood velocity in the middle cerebral arteries (MCA… (More)
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Highly Cited
1990
Highly Cited
1990
1. We describe the actions of GR43175, a 5-hydroxytryptamine1 (5-HT1)-like receptor agonist, on neurogenically-mediated plasma… (More)
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