Triptans

Derivatives of TRYPTAMINES that are SEROTONIN RECEPTOR AGONISTS acting at 5-HT1 RECEPTORS. Some are used to treat MIGRAINE DISORDERS.
National Institutes of Health

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Review
2008
Review
2008
The triptans are a class of tryptamine-based drugs indicated for in the treatment of migraine headaches. The triptans act as… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of… (More)
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Review
2005
Review
2005
Migraine headache is a pervasive but poorly understood primary pain disorder. Sumatriptan and the ‘triptan’ class of serotonin… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Triptans are widely used to treat migraine but have been associated with stroke, myocardial infarction (MI), and… (More)
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Highly Cited
2004
Highly Cited
2004
We have shown that the development of cutaneous allodynia (exaggerated skin sensitivity) during migraine is detrimental to the… (More)
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Review
2003
Review
2003
The triptans are 5-HT(1B/1D) agonists used as migraine and cluster-specific agents. Seven are in commercial use worldwide; in… (More)
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Review
2002
Review
2002
From the Institute of Neurology, National Hospital for Neurology and Neurosurgery, London (P.J.G.); the Departments of Neurology… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Complete withdrawal from headache medication is the treatment of choice for medication-overuse headache… (More)
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2000
2000
Triptans are a new class of compounds developed for the treatment of migraine attacks. The first of the class, sumatriptan, and… (More)
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