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Triptans

Derivatives of TRYPTAMINES that are SEROTONIN RECEPTOR AGONISTS acting at 5-HT1 RECEPTORS. Some are used to treat MIGRAINE DISORDERS.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Background:  Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients’ quality… Expand
Highly Cited
2008
Highly Cited
2008
Background.— Though symptomatic medication overuse is believed to play a major role in progression from episodic to chronic or… Expand
Highly Cited
2004
Highly Cited
2004
For many migraine patients, triptan therapy provides complete pain relief in some attacks but not in others. Here, we tested… Expand
Review
2004
Review
2004
Background.—Health care providers frequently cite concerns about cardiovascular safety of the triptans as a barrier to their use… Expand
Highly Cited
2004
Highly Cited
2004
Background: Triptans are widely used to treat migraine but have been associated with stroke, myocardial infarction (MI), and… Expand
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Highly Cited
2004
Highly Cited
2004
We have shown that the development of cutaneous allodynia (exaggerated skin sensitivity) during migraine is detrimental to the… Expand
Review
2002
Review
2002
The triptans, selective serotonin 5-HT1B/1D agonists, are very effective acute migraine drugs. Soon, seven different triptans… Expand
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Review
2002
Review
2002
Migraine is a common and sometimes debilitating disorder. This review describes the epidemiology, pathophysiology, and preventive… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed… Expand
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Review
2001
Review
2001
The chemical composition of St. John's wort has been well‐studied. Documented pharmacological activities, including… Expand