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Succinate-semialdehyde dehydrogenase

Known as: NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase, Dehydrogenase, Succinic Semialdehyde, Dehydrogenase, Succinate Semialdehyde 
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
010203019542016

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9 relations
ALDH5A1 geneIn BloodProcess of secretionantagonists & inhibitors
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succinic semialdehyde dehydrogenase deficiency

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Succinate-semialdehyde dehydrogenase
physiological aspects
In Blood
chemical synthesis
standards characteristics
Process of secretion

Papers overview

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Highly Cited
2006
Highly Cited
2006
Mutations in antiquitin in individuals with pyridoxine-dependent seizures
We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin… (More)
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2004
2004
A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability
Succinate-semialdehyde dehydrogenase (SSADH) deficiency is a rare cause of learning disability. We have investigated SSADH to… (More)
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2004
2004
Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency.
Mice with targeted deletion of the GABA catabolic enzyme succinic semialdehyde dehydrogenase (SSADH) manifest lethal tonic-clonic… (More)
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2004
2004
Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency.
Murine succinate semialdehyde dehydrogenase (SSADH) deficiency (OMIM 271980; EC 1.2.1.24), a model of the corresponding human… (More)
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Highly Cited
2003
Highly Cited
2003
Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants.
The gamma-aminobutyrate (GABA) shunt is a metabolic pathway that bypasses two steps of the tricarboxylic acid cycle, and it is… (More)
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2002
2002
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
Metabolite profiling in succinate semialdehyde dehydrogenase (SSADH; Aldh5a1-/-) deficient mice previously revealed elevated… (More)
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2002
2002
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
Therapeutic intervention for human succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria) has… (More)
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2001
2001
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase
Succinate semialdehyde dehydrogenase (ALDH5A1, encoding SSADH deficiency is a defect of 4-aminobutyric acid (GABA) degradation… (More)
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Highly Cited
2000
Highly Cited
2000
Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry.
Unknown compounds in polar fractions of Arabidopsis thaliana crude leaf extracts were identified on the basis of calculations of… (More)
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Highly Cited
1999
Highly Cited
1999
Metabolism and functions of gamma-aminobutyric acid.
Gamma-aminobutyric acid (GABA), a four-carbon non-protein amino acid, is a significant component of the free amino acid pool in… (More)
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