I. McGregor

Publications326
h-index68
Citations14,992
Highly Influential Citations758
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The effects of predator odors in mammalian prey species: A review of field and laboratory studies
TLDR
A small number of recent studies have suggested that skin and fur-derived predator odors may have a more profound lasting effect on prey species than those derived from urine or feces. Expand
‘When a rat smells a cat’: the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor
TLDR
Robust Fos expression in the ventromedial hypothalamus, premamillary nucleus and periaqueductal gray confirms previous suggestions of a role for these areas in predator-induced defensive behavior and draws attention to this subregion as a possible interface between olfactory input and emotional output. Expand
Defensive behavior in rats towards predatory odors: a review
TLDR
It is concluded that cat odor is a useful tool for elucidating behavioral, neural, pharmacological and autonomic aspects of defensive behavior and anxiety. Expand
Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure
TLDR
It is suggested that adolescent rats find repeated Δ9-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats. Expand
Not all ‘predator odours’ are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats
TLDR
The results suggest that while cat odour strongly elicits specific defensive behaviours in rats, TMT has effects that are more characteristic of an aversive odour, and some previous studies using TMT may need to be reassessed. Expand
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist.
TLDR
The results show that cannabinoids modulate the motivation for beer via both cannabinoid CB1 receptors and opioid receptors, and suggests that the drug effect may reflect a general stimulatory effect on appetite for palatable beverages, although a more specific effect on the desire for alcohol cannot be ruled out. Expand
Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats
TLDR
It is suggested that chronic exposure to a cannabinoid receptor agonist well after the immediate postnatal period, but before reaching sexual maturity, can lead to increased anxiety and a lasting impairment of working memory. Expand
Aversive effects of the synthetic cannabinoid CP 55,940 in rats
TLDR
It is concluded that CP 55,940 is aversive to rats, and the possible mechanisms underlying this aversion are discussed. Expand
Increased Anxiety 3 Months after Brief Exposure to MDMA (‘Ecstasy’) in Rats: Association with Altered 5-HT Transporter and Receptor Density
TLDR
Interestingly, long-term 5-HT depletion may not be necessary to produce lasting effects on anxiety-like behavior after low-dose MDMA, suggesting that even brief, relatively low- dose MDMA exposure can produce significant,Long-term changes in5-HT receptor and transporter function and associated emotional behavior. Expand
Breaking the loop: Oxytocin as a potential treatment for drug addiction
TLDR
Oxytocin has fascinating potential to reverse the corrosive effects of long-term drugs abuse on social behavior and to perhaps inoculate against future vulnerability to addictive disorders. Expand
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