Subtilisin

Known as: Subtilisin [Chemical/Ingredient] 
A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
020040019542016

Papers overview

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Highly Cited
2012
Highly Cited
2012
OBJECTIVES The primary objective of this study was to evaluate the low-density lipoprotein cholesterol (LDL-C)-lowering efficacy… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND LDL cholesterol (LDL-C) is a well established risk factor for cardiovascular disease. Proprotein convertase subtilisin… (More)
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Highly Cited
2009
Highly Cited
2009
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL… (More)
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Highly Cited
2007
Highly Cited
2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of hepatic low density lipoprotein receptors (LDLR… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart… (More)
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Highly Cited
2004
Highly Cited
2004
Lipid homeostasis is transcriptionally regulated by three DNA-binding proteins, designated sterol regulatory element-binding… (More)
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Highly Cited
2003
Highly Cited
2003
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an… (More)
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Highly Cited
2000
Highly Cited
2000
Stomata are specialized cellular structures in the epidermis of aerial plant organs that control gas exchange (H(2)O release and… (More)
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Highly Cited
1999
Highly Cited
1999
We used directed evolution to convert Bacillus subtilis subtilisin E into an enzyme functionally equivalent to its thermophilic… (More)
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Highly Cited
1992
Highly Cited
1992
Many viruses have membrane glycoproteins that are activated at cleavage sites containing multiple arginine and lysine residues by… (More)
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