• Publications
  • Influence
Solvent content of protein crystals.
  • B. Matthews
  • Chemistry, Medicine
  • Journal of molecular biology
  • 28 April 1968
Abstract An analysis has been made, from the data which are currently available, of the solvent content of 116 different crystal forms of globular proteins. The fraction of the crystal volumeExpand
  • 7,399
  • 2297
Comparison of the predicted and observed secondary structure of T4 phage lysozyme.
  • B. Matthews
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 20 October 1975
Predictions of the secondary structure of T4 phage lysozyme, made by a number of investigators on the basis of the amino acid sequence, are compared with the structure of the protein determinedExpand
  • 3,201
  • 564
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect.
Six "cavity-creating" mutants, Leu46----Ala (L46A), L99A, L118A, L121A, L133A, and Phe153----Ala (F153A), were constructed within the hydrophobic core of phage T4 lysozyme. The substitutionsExpand
  • 818
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  • PDF
An efficient general-purpose least-squares refinement program for macromolecular structures
A package of programs has been developed for efficient restrained least-squares refinement of macromolecular crystal structures. The package has been designed to be as flexible and general purpose asExpand
  • 699
  • 32
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Structural basis for the attachment of a paramyxoviral polymerase to its template.
The nucleocapsid of measles virus is the template for viral RNA synthesis and is generated through packaging of the genomic RNA by the nucleocapsid protein (N). The viral polymerase associates withExpand
  • 172
  • 25
Accurate calculation of the density of proteins.
On the basis of theoretical calculations, Andersson & Hovmöller have recently suggested that the long-established value of 1.35 g cm(-3) for the mean density of proteins should be revised to 1.22 gExpand
  • 182
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Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
The three-dimensional structure of BirA, the repressor of the Escherichia coli biotin biosynthetic operon, has been determined by x-ray crystallography and refined to a crystallographic residual ofExpand
  • 258
  • 17
The response of T4 lysozyme to large‐to‐small substitutions within the core and its relation to the hydrophobic effect
To further examine the structural and thermodynamic basis of hydrophobic stabilization in proteins, all of the bulky non‐polar residues that are buried or largely buried within the core of T4Expand
  • 209
  • 14
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Structure and function of the methionine aminopeptidases.
The removal of the N-terminal methionine from proteins and peptides is dependent upon a novel class of proteases typified by the dinuclear metalloenzyme methionine aminopeptidase from EscherichiaExpand
  • 256
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