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Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop.
New guidelines for management of asymptomatic primary hyperparathyroidism have been revised and a blueprint for future research is proposed to foster additional investigation into issues that remain uncertain or controversial. Expand
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both…
- A. Abou-Samra, H. Jüppner, +7 authors J. Potts
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1992
Using expression cloning, a cDNA clone is isolated encoding rat bone PTH/PTHrP receptor from rat osteosarcoma cells that is 78% identical to the opossum kidney receptor and indicates striking conservation of this receptor across distant mammalian species. Expand
Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop.
This report guides the use of diagnostics and management for this condition in clinical practice by establishing consensus at a group meeting and at subsequent discussions. Expand
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.
- S. Ferrandon, T. Feinstein, +5 authors J. Vilardaga
- Biology, Medicine
- Nature chemical biology
- 23 August 2009
Analyzing the ligand response by measuring the kinetics of activation and deactivation for each individual reaction step along the PTHR signaling cascade found that during the time frame of G protein coupling and cAMP production, PTHrP action was restricted to the cell surface, whereas PTH(1-34) had moved to internalized compartments where it remained associated with the P THR and Galpha(s), potentially as a persistent and active ternary complex. Expand
Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism. Expand
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
Striking homology with the calcitonin receptor and lack of homological with other G protein-linked receptors indicate that receptors for these calcium-regulating hormones are related and represent a new family. Expand
Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century.
- J. Bilezikian, J. Potts, +7 authors S. Wells
- The Journal of clinical endocrinology and…
- 1 November 2002
Department of Medicine, Columbia University College of Physicians and Surgeons (J.P.B., S.J.N.), Boston, Massachusetts 02114; Department of Surgery, Duke University Medical Center (S.A.W.), Durham, North Carolina 27710. Expand
Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target‐organ involvement, treatment, and challenges for future research
- J. Bilezikian, A. Khan, +14 authors J. Sanders
- Journal of bone and mineral research : the…
- 1 October 2011
This review, which focuses primarily on hypoparathyroidism in the adult, provides a comprehensive summary of the latest information on this disease. Expand
Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.
Those patients who had the largest increases in 47Ca-kinetic and histomorphometric indices of new bone formation showed the greatest increases in trabecular bone volume, suggesting that treatment with human parathyroid hormone fragment caused a dissociation between formation and resorption rates that was confined to trabECular bone. Expand
Photosynthesis of previtamin D3 in human skin and the physiologic consequences.
These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D3 from the skin into the circulation. Expand