Steroid 17-alpha-Hydroxylase

Known as: alpha 17 hydroxylase, Steroid 17 alpha Hydroxylase, CYP17 
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual… (More)
National Institutes of Health

Related topics

Related topics

22 relations
CYP17A1 geneCYP17A1 wt AlleleCongenital adrenal hyperplasiaEnzyme Gene
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Broader (2)

Cytochrome P450 Family 17Oxygenases

Papers overview

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Review
2004
Review
2004
Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders.
Stress promotes adaptation, but prolonged stress leads over time to wear-and-tear on the body (allostatic load). Neural changes… (More)
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Review
2003
Review
2003
Mood disorders and allostatic load
The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the… (More)
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Highly Cited
1999
Highly Cited
1999
Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2).
Prostate cancer is the most common malignancy in males and is the second most common cause of cancer mortality in American men… (More)
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Highly Cited
1995
Highly Cited
1995
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.
Steroidal compounds having a 17-(3-pyridyl) substituent together with a 16,17-double bond have been synthesized, using a… (More)
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Highly Cited
1994
Highly Cited
1994
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
Medical or surgical castration for the treatment of prostatic cancers prevents androgen production by the testes, but not by the… (More)
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Review
1994
Review
1994
Disorders of steroid 17 alpha-hydroxylase deficiency.
The human P450c17 alpha gene (CYP17) is a single copy gene located in chromosome 10, consisting of 8 exons and 7 introns. 17… (More)
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1993
1993
Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.
Cytochrome P450c17 (EC 1.14.99.9) catalyzes both 17 alpha-hydroxylase and 17,20-lyase activities in mammalian steroidogenesis and… (More)
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Highly Cited
1991
Highly Cited
1991
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.
When the cDNA encoding bovine microsomal 17 alpha-hydroxylase cytochrome P450 (P45017 alpha) containing modifications within the… (More)
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Highly Cited
1987
Highly Cited
1987
Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21.
P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of… (More)
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Highly Cited
1987
Highly Cited
1987
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase… (More)
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