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CYP17A1 gene

Known as: CYP17, S17AH, CYTOCHROME P450, SUBFAMILY XVII 
This gene plays a role in the metabolism of estrogen and glucocorticoids. It is also involved in sexual maturation.
National Institutes of Health

Related topics

Related topics

9 relations
Adrenal Cortical HyperplasiaIron ChelationMetabolic Detoxication, DrugMetabolism

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CYP17A1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes
Evidence has shown that polymorphisms of various genes known to be involved in estrogen biosynthesis and function are associated… 
Review
2009
Review
2009
Androgen synthesis in adrenarche
The enzymes and pathways of steroidogenesis are central to an understanding of adrenarche. The quantitative regulation of… 
Highly Cited
2009
Highly Cited
2009
Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents.
The CYP17A1 gene is the qualitative regulator of steroidogenesis. Depending on the presence or absence of CYP17 activities… 
Highly Cited
2002
Highly Cited
2002
The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis.
Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and… 
Highly Cited
2001
Highly Cited
2001
Thiazolidinediones but Not Metformin Directly Inhibit the Steroidogenic Enzymes P450c17 and 3β-Hydroxysteroid Dehydrogenase*
Androgen biosynthesis requires 3β-hydroxysteroid dehydrogenase type II (3βHSDII) and the 17α-hydroxylase and 17,20-lyase… 
Highly Cited
2001
Highly Cited
2001
The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer.
The A2 allele of the CYP17 gene has been thought to be associated with increased functional activity of this steroidogenic enzyme… 
Highly Cited
2001
Highly Cited
2001
Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
The cytochrome P450c17 enzyme system performs both the 17alpha-hydroxylase and 17,20-lyase reactions in the human adrenal glands… 
Highly Cited
1999
Highly Cited
1999
The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.
The A2 allele of CYP17 has been associated with polycystic ovarian syndrome, elevated levels of certain steroid hormones in… 
Highly Cited
1998
Highly Cited
1998
NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.
In addition to their endogenous roles as an activation system for various Escherichia coli metabolic pathways, the soluble… 
1997
1997
The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.
Studies are reported showing that recombinant P450c17, coexpressed with rat NADPH-P450 reductase or expressed as a fusion protein… 
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