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CYP17A1 gene

Known as: CYP17, S17AH, CYTOCHROME P450, SUBFAMILY XVII 
This gene plays a role in the metabolism of estrogen and glucocorticoids. It is also involved in sexual maturation.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The CYP17A1 gene is the qualitative regulator of steroidogenesis. Depending on the presence or absence of CYP17 activities… Expand
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Review
2008
Review
2008
A period of oocyte growth is followed by a process called oocyte maturation (the resumption of meiosis) which occurs prior to… Expand
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Review
2008
Review
2008
  • W. Miller
  • Endocrine development
  • 2008
  • Corpus ID: 207564842
The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the biochemistry and molecular biology of… Expand
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Review
2008
Review
2008
  • W. Miller
  • Reviews in Endocrine and Metabolic Disorders
  • 2008
  • Corpus ID: 6057052
The enzymes and pathways of steroidogenesis are central to an understanding of adrenarche. The quantitative regulation of… Expand
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Highly Cited
2004
Highly Cited
2004
Abstract Androgens are an integral part of human physiology. The de novo production of androgens is generally limited to the… Expand
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Highly Cited
2002
Highly Cited
2002
Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and… Expand
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Highly Cited
1999
Highly Cited
1999
The A2 allele of CYP17 has been associated with polycystic ovarian syndrome, elevated levels of certain steroid hormones in… Expand
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Highly Cited
1998
Highly Cited
1998
In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17α-hydroxylation of 21-carbon… Expand
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Highly Cited
1995
Highly Cited
1995
Microsomal cytochrome P450c17 catalyzes both steroid 17 alpha-hydroxylase activity and scission of the C17-C20 steroid bond (17… Expand
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Highly Cited
1987
Highly Cited
1987
P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of… Expand
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