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CYP17A1 wt Allele
Known as:
Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 wt Allele
, S17AH
, CYP17
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Human CYP17A1 wild-type allele is located in the vicinity of 10q24.3 and is approximately 7 kb in length. This allele, which encodes cytochrome P450…
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National Institutes of Health
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Related topics
Related topics
10 relations
10q24.3
Adrenal Cortical Hyperplasia
Iron Chelation
Metabolic Detoxication, Drug
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Broader (1)
CYP17A1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-α
A. C. Millena
,
Sheila Reddy
,
Gretchen H. Bowling
,
Shafiq A. Khan
Molecular and Cellular Endocrinology
2004
Corpus ID: 32119998
Highly Cited
1999
Highly Cited
1999
Repeated use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome.
L. Pratt
,
R. Magness
,
T. Phernetton
,
S. Hendricks
,
D. Abbott
,
I. Bird
American Journal of Obstetrics and Gynecology
1999
Corpus ID: 395324
Highly Cited
1998
Highly Cited
1998
Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells.
C. Cascio
,
V. Prasad
,
Y. Y. Lin
,
S. Lieberman
,
Vassilios Papadopoulos
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 24831073
Dehydroepiandrosterone (D) is biosynthesized in the brain by a pathway different from that existing in the adrenal cortex. C6 rat…
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Highly Cited
1998
Highly Cited
1998
Immunoexpression of the steroidogenic enzymes 3-beta hydroxysteroid dehydrogenase and 17 alpha-hydroxylase, C17,20 lyase and the receptor for luteinizing hormone (LH) in the fetal rat testis suggests…
G. Majdič
,
Philippa T. K. Saunders
,
K. Teerds
Biology of Reproduction
1998
Corpus ID: 26202388
The production of testosterone in the adult testis is mainly regulated by LH. Testosterone is essential for normal development of…
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1998
1998
The Regulation of Human P450c17 Activity: Relationship to Premature Adrenarche, Insulin Resistance and the Polycystic Ovary Syndrome
R. Auchus
,
D. Geller
,
Tim C. Lee
,
W. Miller
Trends in endocrinology and metabolism
1998
Corpus ID: 42317313
Highly Cited
1995
Highly Cited
1995
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.
N. Compagnone
,
Alessandro Bulfone
,
J. Rubenstein
,
S. Mellon
Endocrinology
1995
Corpus ID: 46278922
Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids…
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Highly Cited
1994
Highly Cited
1994
Modeling and mutagenesis of the active site of human P450c17.
Dong Lin
,
Lin-Hua Zhang
,
E. Chiao
,
Walter L. Miller
Molecular Endocrinology
1994
Corpus ID: 23242781
Cytochrome P450c17 is the single enzyme having steroid 17 alpha-hydroxylase and 17,20 lyase activities. We sought to model the…
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Highly Cited
1993
Highly Cited
1993
Expression in Escherichia coli of functional cytochrome P450c17 lacking its hydrophobic amino-terminal signal anchor.
Y. Sagara
,
H. Barnes
,
M. Waterman
Archives of Biochemistry and Biophysics
1993
Corpus ID: 21399784
A truncated form of bovine microsomal 17 alpha-hydroxylase cytochrome P450 (P450c17) lacking its amino-terminal hydrophobic…
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1992
1992
The role of cytokines in the regulation of Leydig cell P450c17 gene expression
D. B. Hales
,
Y. Xiong
,
I. Tur-Kaspa
Journal of Steroid Biochemistry and Molecular…
1992
Corpus ID: 7839029
Highly Cited
1990
Highly Cited
1990
Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes.
M. Shibata
,
T. Sakaki
,
Y. Yabusaki
,
H. Murakami
,
H. Ohkawa
DNA and Cell Biology
1990
Corpus ID: 26241641
Seven P450/reductase fused enzymes were produced in Saccharomyces cerevisiae by expressing fused cDNAs consisting of bovine…
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