Steroid 11-beta-Monooxygenase

Known as: Cytochrome P-450(11 beta), Steroid 11-Beta-Hydroxylase, Steroid 11 beta Hydroxylase 
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH… (More)
National Institutes of Health

Related topics

Related topics

26 relations
Adrenogenital SyndromeAldosterone SynthaseCYP11B1 geneCYP11B1 wt Allele
(More)

Narrower (1)

Cyp11c1 protein, zebrafish

Broader (2)

Cytochrome P450Oxygenases

Papers overview

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Highly Cited
2010
Highly Cited
2010
Adrenocortical zonation in humans under normal and pathological conditions.
CONTEXT Aldosterone synthase (CYP11B2) and steroid 11 beta-hydroxylase (CYP11B1) catalyze the terminal steps for aldosterone and… (More)
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Review
2008
Review
2008
Use of vitamin D in clinical practice.
The recent discovery--from a meta-analysis of 18 randomized controlled trials--that supplemental cholecalciferol (vitamin D… (More)
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Highly Cited
2003
Highly Cited
2003
Total biosynthesis of hydrocortisone from a simple carbon source in yeast
We report on the production of hydrocortisone, the major adrenal glucocorticoid of mammals and an important intermediate of… (More)
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Review
2001
Review
2001
Environment and sex determination in farmed fish.
A plasticity of gonadal sex differentiation was reported in the 1930s following exogenous steroid treatments in fish, but… (More)
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Highly Cited
1992
Highly Cited
1992
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.
We proposed that a cell-selective regulatory protein coordinately regulates the expression of three enzymes that are required for… (More)
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Highly Cited
1992
Highly Cited
1992
21-hydroxylase, a major autoantigen in idiopathic Addison's disease
Sera from patients with idiopathic Addison's disease commonly react with the zona glomerulosa of adrenal cortex. We used high… (More)
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Highly Cited
1992
Highly Cited
1992
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Patients with glucocorticoid-remediable aldosteronism (GRA) from 12 kindreds possess chimaeric gene duplications arising from… (More)
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Highly Cited
1990
Highly Cited
1990
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
We established a continuous cell line, NCI-H295, from an invasive primary adrenocortical carcinoma. The cell line was established… (More)
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Highly Cited
1989
Highly Cited
1989
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
Steroid 11 beta-hydroxylase (P-450(11) beta) is a mitochondrial cytochrome P-450 enzyme necessary for cortisol biosynthesis… (More)
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Highly Cited
1984
Highly Cited
1984
Inhibition of adrenal steroidogenesis by the anesthetic etomidate.
The use of the intravenous anesthetic etomidate for prolonged sedation has been associated with low levels of plasma cortisol and… (More)
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