Skip to search formSkip to main contentSkip to account menu

Spleen

Known as: Splen, spleno, Reticuloendothelial System, Spleen 
An organ that is part of the hematopoietic and immune systems. It is composed of the white pulp and the red pulp and is surrounded by a capsule. It… 
National Institutes of Health

Related topics

Related topics

43 relations
Absent in melanoma 2 proteinBMP2 protein, humanCASP4 protein, humanCCBP2 protein, human

Broader (2)

Corticomedullary organLymphoid Tissue

Narrower (3)

Parenchyma of spleenSplenectomyStormorken Syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development
Distinct dendritic cell (DC) subsets have been suggested to be preprogrammed to direct either T helper cell (Th) type 1 or Th2… 
Highly Cited
2000
Highly Cited
2000
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major… 
Review
1998
Review
1998
The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
For many viral infections, resolution of illness is associated with long-term host control of viremia rather than viral… 
Highly Cited
1996
Highly Cited
1996
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by… 
Highly Cited
1993
Highly Cited
1993
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned and expressed. The present study… 
Highly Cited
1992
Highly Cited
1992
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
To address the mechanisms controlling T helper (Th) phenotype development, we used DO10, a transgenic mouse line that expresses… 
Review
1989
Review
1989
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
B lymphocytes can be rendered specifically unresponsive to antigen by experimental manipulation in vivo and in vitro1–6, but it… 
Highly Cited
1987
Highly Cited
1987
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
An early event in death of interphase lymphocytes exposed in vivo or in vitro to low doses of gamma-irradiation is the… 
Highly Cited
1981
Highly Cited
1981
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2
The site of action of the immunosuppressive drug cyclosporin A in in vitro cytotoxic allograft responses has been localized… 
Highly Cited
1969
Highly Cited
1969
Thrombokinetics in man.
Platelet production, distribution, and destruction have been quantitated in normal man and in selected patients with platelet… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)