Absent in melanoma 2 protein

Known as: AIM2, Absent in Melanoma 2, Interferon-Inducible Protein AIM2 
Interferon-inducible protein AIM2 (343 aa, ~39 kDa) is encoded by the human AIM2 gene. This protein may be involved in apoptosis, inflammation and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
051020052017

Papers overview

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2016
2016
The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of… (More)
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Highly Cited
2015
Highly Cited
2015
The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of… (More)
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2015
2015
Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is… (More)
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2013
Highly Cited
2013
Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for… (More)
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2013
2013
Francisella tularensis is an important human pathogen responsible for causing tularemia. F. tularensis has long been developed as… (More)
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2013
2013
Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and… (More)
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2011
2011
BACKGROUND The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro… (More)
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2010
Highly Cited
2010
Infection with Listeria monocytogenes can cause meningitis and septicemia in newborn, elderly, or immunocompromised individuals… (More)
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2009
Highly Cited
2009
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and… (More)
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2009
Highly Cited
2009
Cytoplasmic DNA triggers activation of the innate immune system. Although 'downstream' signaling components have been… (More)
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