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Spiperone

Known as: Spiroperidol, Spiperone [Chemical/Ingredient], 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl- 
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (14)

((carboxymethylene)oximino)spiperone-sepharose 4B2'-iodospiperone3-N-(2-fluoroethyl)spiperone3-N-methylspiperone

Broader (2)

Antipsychotic AgentsDopamine Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Is there a relationship between the involvement of extrapyramidal and mesolimbic brain areas with the cataleptic action of neuroleptic agents and their clinical antipsychotic effect?
The electrolytic brain lesion technique was used in the rat to disrupt the ascending dopaminergic pathways to the extrapyramidal… 
1986
1986
On the presence of a nondopaminergic, peptidergic prolactin release-inhibiting factor in hypothalamic extracts of infantile rats.
Crude hypothalamic extracts prepared from brains of 1-day-old rats produced a dose-dependent inhibition of prolactin (Prl… 
1985
1985
Presence of high affinity dopamine receptors in estrone-induced, prolactin-secreting rat pituitary adenomas: a model for human prolactinomas.
Adenomatous cells obtained from a pituitary tumor induced in Fisher 344/Lis rats by the subcutaneous implantation of estrone (E1… 
1985
1985
Action of antidepressant neuroleptics, chlorprothixene and levomepromazine, on the central noradrenergic system: comparison with other antidepressants.
In contrast to imipramine, chlorprothixene (CPX) and levomepromazine (LMZ) given chronically did not affect clonidine-induced… 
1983
1983
Modulatory interactions between enkephalin and catecholamines: anatomical and physiological substrates.
The anatomical and electrophysiological basis of enkephalin-catecholamine interactions was studied in the central nervous system… 
1983
1983
Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide.
Two chemical analogs of pergolide were examined to test further the idea that pergolide elevates serum corticosterone… 
1982
1982
Effect of α-Melanocyte-Stimulating Hormone on Basal and Stimulated Release of Prolactin:Evidence for Dopaminergic Mediation
The effects of α-melanocyte-stimulating hormone (α-MSH) on basal and stimulated release of prolactin were studied… 
1981
1981
Differential inhibitory effects of ascorbic acid on the binding of dopamine agonists and antagonists to neostriatal membrane preparations: correlations with behavioral effects.
Ascorbic acid was a potent inhibitor of the binding of both dopamine agonists (3H-dopamine and 3H-ADTN) and also of dopamine… 
1980
1980
Lack of evidence that the central serotoninergic system plays a role in the activation of prolactin secretion following inhibition of dopamine synthesis or blockade of dopamine receptors in the male…
Administration of alpha MT to inhibit catecholamine synthesis or dopamine (DA) receptor blockade with spiroperidol had no effect… 
1977
1977
5-Methoxytryptamine-induced head twitches in rats.
In rats pretreated with pargyline ip injection of 5-methoxytryptamine (5-MT), but not of 5-HT, produced characteristic head…