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Spiperone

Known as: Spiroperidol, Spiperone [Chemical/Ingredient], 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl- 
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (14)

((carboxymethylene)oximino)spiperone-sepharose 4B2'-iodospiperone3-N-(2-fluoroethyl)spiperone3-N-methylspiperone

Broader (2)

Antipsychotic AgentsDopamine Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Is there a relationship between the involvement of extrapyramidal and mesolimbic brain areas with the cataleptic action of neuroleptic agents and their clinical antipsychotic effect?
The electrolytic brain lesion technique was used in the rat to disrupt the ascending dopaminergic pathways to the extrapyramidal… 
1986
1986
Purification of bovine striatal dopamine D-2 receptor by affinity chromatography.
Bovine striatal dopamine D-2 receptor has been purified approximately 2000-fold by affinity chromatography. The receptor… 
1985
1985
Presence of high affinity dopamine receptors in estrone-induced, prolactin-secreting rat pituitary adenomas: a model for human prolactinomas.
Adenomatous cells obtained from a pituitary tumor induced in Fisher 344/Lis rats by the subcutaneous implantation of estrone (E1… 
1983
1983
Modulatory interactions between enkephalin and catecholamines: anatomical and physiological substrates.
The anatomical and electrophysiological basis of enkephalin-catecholamine interactions was studied in the central nervous system… 
1982
1982
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.
The enantiomers (6aR and 6aS) of 2,10,11-trihydroxyaporphine (THA) were synthesized from thebaine and bulbocapnine and evaluated… 
1982
1982
Effect of α-Melanocyte-Stimulating Hormone on Basal and Stimulated Release of Prolactin:Evidence for Dopaminergic Mediation
The effects of α-melanocyte-stimulating hormone (α-MSH) on basal and stimulated release of prolactin were studied… 
1982
1982
The effect of the alkaloid (-)cathinone on the motor activity in mice.
Khat leaves, widely used as a stimulant in East Africa and the Arab Peninsula, contain the alkaloid, (-)cathinone. This substance… 
1981
1981
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.
Analogues of clozapine, some prepared by a novel, shorter synthesis than those described previously, were evaluated as potential… 
1981
1981
Differential inhibitory effects of ascorbic acid on the binding of dopamine agonists and antagonists to neostriatal membrane preparations: correlations with behavioral effects.
Ascorbic acid was a potent inhibitor of the binding of both dopamine agonists (3H-dopamine and 3H-ADTN) and also of dopamine… 
1980
1980
Lack of evidence that the central serotoninergic system plays a role in the activation of prolactin secretion following inhibition of dopamine synthesis or blockade of dopamine receptors in the male…
Administration of alpha MT to inhibit catecholamine synthesis or dopamine (DA) receptor blockade with spiroperidol had no effect… 
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