Skip to search formSkip to main contentSkip to account menu

Spiperone

Known as: Spiroperidol, Spiperone [Chemical/Ingredient], 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl- 
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (14)

((carboxymethylene)oximino)spiperone-sepharose 4B2'-iodospiperone3-N-(2-fluoroethyl)spiperone3-N-methylspiperone

Broader (2)

Antipsychotic AgentsDopamine Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1986
Highly Cited
1986
Guanine nucleotide regulation of agonist interactions at [3H]SCH23390-labeled D1 dopamine receptors in rat striatum.
Highly Cited
1984
Highly Cited
1984
Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.
Highly Cited
1983
Highly Cited
1983
Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord.
Highly Cited
1983
Highly Cited
1983
Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine… 
Highly Cited
1980
Highly Cited
1980
Effect of age on adrenergic and dopaminergic receptor binding in rat brain.
Highly Cited
1978
Highly Cited
1978
Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity.
Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of… 
Highly Cited
1978
Highly Cited
1978
3H-Spiroperidol labels serotonin receptors in rat cerebral cortex and hippocampus.
Highly Cited
1978
Highly Cited
1978
Dopamine receptor binding in vivo: the feasibility of autoradiographic studies.
Highly Cited
1978
Highly Cited
1978
3H-Spiroperidol binding to two receptor sites in both the corpus striatum and frontal cortex of rat brain.
Highly Cited
1971
Highly Cited
1971
Importance of nervous impulse flow for the neuroleptic induced increase in amine turnover in central dopamine neurons.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)