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Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical
TLDR
It is suggested that both TIQ and 1MeTIQ may be effective for the therapy of depression in clinic as new antidepressants which, when administered peripherally easily penetrate the blood–brain barrier, and as endogenous compounds may not have adverse side effects. Expand
Effects of various Ca2+ channel antagonists on morphine analgesia, tolerance and dependence, and on blood pressure in the rat.
TLDR
All three Ca2+ antagonists enhanced the analgesia, and prevented development of the naloxone-precipitated withdrawal syndrome, although they differed in their efficacy. Expand
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
TLDR
The results indicate that the symptoms of abstinence are related to a functional state of cortical dihydropyridine-sensitive calcium channels in morphine-dependent, naloxone-treated rats. Expand
Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action.
TLDR
The obtained results suggest that the anti-immobility effect of CP 94253 is mediated by activation of 5-HT(1B) receptors-most probably located postsynaptically and/or as heteroreceptors, and that the dopamine and the noradrenaline systems are involved in this action. Expand
Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines.
TLDR
Therapeutic strategies should focused on the search for the drugs exhibiting antiapoptotic potential such as: antioxidants, MAOB inhibitors, dopaminergic drugs and free radical scavengers. Expand
Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats
TLDR
An appearance of cardinal neurochemical and histological changes of parkinsonian type only after intranigral lactacystin injection indicates that DA cell bodies in the SN, but not DA terminals in the striatum are susceptible to proteasome inhibition. Expand
Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures.
TLDR
A close relationship between the peripheral vagus nerve impairment and the inhibition of dopamine system in the brain structures is suggested, the first report of such relationship which may suggest that mental changes could occur in the first stage of Parkinson's disease far ahead of motor impairment. Expand
Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model
TLDR
Stress- and drug-induced effects on beta1-adrenoceptors do not appear to be a common biochemical marker of antidepressant-like activity in the CMS model, and consistency changes of Kd values and of cAMP responses to noradrenaline (NA) stimulation were observed. Expand
Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain.
TLDR
It is demonstrated for the first time that L-NA may alter the neurotransmitter utilization in vivo and the observed effect may be due to adaptational changes in neuronal function. Expand
The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells
TLDR
The present data indicate that memantine attenuates the toxic effects of various proapoptotic agents and the cytoprotective effect of memantine does not seem to be connected with its action on NMDA receptor but rather with its influence on intracellular pathways engaged in cellular survival/apoptosis processes. Expand
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