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Solute Carrier Family 12, Member 3

Known as: SLC12A3 Protein, Na Cl Cotransporter, Cotransporter, Na-Cl Thiazide-Sensitive 
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited… 
National Institutes of Health

Related topics

Related topics

11 relations
Gitelman SyndromeIn BloodProcess of secretionSLC12A3 gene

Broader (1)

Sodium Chloride Symporters

Papers overview

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Highly Cited
2011
Highly Cited
2011
Spectrum of mutations in Gitelman syndrome.
Gitelman's syndrome (GS) is a rare, autosomal recessive, salt-losing tubulopathy caused by mutations in the SLC12A3 gene, which… 
Review
2010
Review
2010
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.
Review
2007
Review
2007
Functional significance of channels and transporters expressed in the inner ear and kidney.
A number of ion channels and transporters are expressed in both the inner ear and kidney. In the inner ear, K(+) cycling and… 
Highly Cited
2007
Highly Cited
2007
Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis
Enhanced lipid peroxidation is well established in traumatic brain injury. However, its molecular targets, identity of… 
Highly Cited
2003
Highly Cited
2003
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4
Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause… 
Highly Cited
2003
Highly Cited
2003
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic… 
Highly Cited
2002
Highly Cited
2002
Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies.
Highly Cited
2001
Highly Cited
2001
The Membrane-type Collectin CL-P1 Is a Scavenger Receptor on Vascular Endothelial Cells*
Collectins are a family of C-type lectins that have collagen-like sequences and carbohydrate recognition domains (CRD). They are… 
Highly Cited
1999
Highly Cited
1999
Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.
We isolated and characterized a novel K-Cl cotransporter, KCC3, from human placenta. The deduced protein contains 1,150 amino… 
Highly Cited
1995
Highly Cited
1995
Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney.
An electroneutral thiazide-sensitive Na-Cl cotransport pathway (TSC) has been localized functionally to the distal convoluted… 
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