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Solute Carrier Family 12, Member 3

Known as: SLC12A3 Protein, Na Cl Cotransporter, Cotransporter, Na-Cl Thiazide-Sensitive 
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited… 
National Institutes of Health

Related topics

Related topics

11 relations
Gitelman SyndromeIn BloodProcess of secretionSLC12A3 gene

Broader (1)

Sodium Chloride Symporters

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Basolateral Kir4.1 activity in the distal convoluted tubule regulates K secretion by determining NaCl cotransporter activity
Purpose of reviewRenal potassium (K) secretion plays a key role in maintaining K homeostasis. The classic mechanism of renal K… 
2008
2008
Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome.
BACKGROUND Loss-of-function mutations in SLC12A3 coding for the thiazide-sensitive NaCl cotransporter (NCC) cause Gitelman's… 
2006
2006
Facilitated Chloride Transport Across Phosphatidylcholine Bilayers by an Acyclic Calixarene Derivative: Structure-Function Relationships
As the field of anion transport develops, it becomes increasingly important to understand mechanistic and structure-function… 
2003
2003
Identification of novel mutations in Na-Cl cotransporter gene in a Korean patient with atypical Gitelman's syndrome.
The authors report the case of a 20-year-old man with unexplained hypokalemia and metabolic alkalosis suggesting hypokalemic… 
2002
2002
Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter.
The thiazide-sensitive sodium-chloride cotransporter (NCC) is expressed by distal convoluted tubule cells of the mammalian kidney… 
1998
1998
Na+-K+-Cl-cotransport in human fibroblasts is inhibited by cytomegalovirus infection.
We examined the effects of human cytomegalovirus (HCMV) infection on the Na+-K+-Cl-cotransporter (NKCC) in a human fibroblast… 
Highly Cited
1996
Highly Cited
1996
Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families
Abstract. Gitelman syndrome is a mostly autosomal recessive disorder affecting the renal tubular function associated with… 
1992
1992
Probing the active site of the reconstituted aspartate/glutamate carrier from mitochondria. Structure/function relationship involving one lysine and two cysteine residues.
Treatment of the reconstituted aspartate/glutamate carrier from mitochondria with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (Nbd-Cl… 
1990
1990
Volume-sensitive K-Cl cotransport in inside-out vesicles made from erythrocyte membranes from sheep of low-K phenotype.
Unidirectional K ion effluxes were measured from inside-out vesicles prepared from erythrocyte membranes from sheep of the low-K… 
1975
1975
Halide uptake by the filamentous ascomycete Neocosmospora vasinfecta
The uptake of Cl minus by the ascomycetes Neocosmospora vasinfecta was investigated. Intramycelial concentrations of more than 55… 
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