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Solute Carrier Family 12, Member 3

Known as: SLC12A3 Protein, Na Cl Cotransporter, Cotransporter, Na-Cl Thiazide-Sensitive 
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited… 
National Institutes of Health

Related topics

Related topics

11 relations
Gitelman SyndromeIn BloodProcess of secretionSLC12A3 gene

Broader (1)

Sodium Chloride Symporters

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Molecular Identities and ATP Release Activities of Two Types of Volume-Regulatory Anion Channels, VSOR and Maxi-Cl.
Review
2009
Review
2009
Regulation of magnesium reabsorption in DCT
The distal convoluted tubule (DCT) is the shortest segment of the nephron and consists of an early (DCT1) and late part (DCT2… 
Highly Cited
2006
Highly Cited
2006
Affinity-defining Domains in the Na-Cl Cotransporter
The thiazide-sensitive Na+-Cl- cotransporter (NCC) is the major pathway for salt reabsorption in the distal convoluted tubule… 
2004
2004
Antibacterial Titanium Plate Anodized by being Discharged in NaCl Solution Exhibits Cell Compatibility
Implant surfaces should be modified to achieve excellent cell compatibility as well as antibacterial activity. Our previous study… 
2002
2002
Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter.
The thiazide-sensitive sodium-chloride cotransporter (NCC) is expressed by distal convoluted tubule cells of the mammalian kidney… 
Highly Cited
2000
Highly Cited
2000
Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue.
K-Cl cotransporters (KCC) play fundamental roles in ionic and osmotic homeostasis. To date, four mammalian KCC genes have been… 
Highly Cited
2000
Highly Cited
2000
Novel mutations in thiazide-sensitive Na-Cl cotransporter gene of patients with Gitelman's syndrome.
Gitelman's syndrome (GS) is an autosomal recessive disorder characterized by metabolic alkalosis, hypokalemia, hypomagnesemia… 
2000
2000
The transport properties of the human renal Na(+)- dicarboxylate cotransporter under voltage-clamp conditions.
The transport properties of the human Na(+)-dicarboxylate cotransporter, (hNaDC-1), expressed in Xenopus laevis oocytes were… 
Highly Cited
1996
Highly Cited
1996
Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families
Abstract. Gitelman syndrome is a mostly autosomal recessive disorder affecting the renal tubular function associated with… 
Highly Cited
1994
Highly Cited
1994
Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases
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