Solute Carrier Family 12, Member 3

Known as: SLC12A3 Protein, Na Cl Cotransporter, Cotransporter, Na-Cl Thiazide-Sensitive 
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2018
0204019642018

Related topics

Related topics

11 relations
Gitelman SyndromeIn BloodProcess of secretionSLC12A3 gene
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Broader (1)

Sodium Chloride Symporters

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Solute Carrier Family 12, Member 3
standards characteristics
physiological aspects
chemical synthesis
Gitelman Syndrome
Sodium Chloride Symporters

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mutations in Kelch-like 3 and Cullin 3 cause hypertension and electrolyte abnormalities
Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease… (More)
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Highly Cited
2011
Highly Cited
2011
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
Rheumatoid arthritis is associated with the development of autoantibodies to citrullinated self-proteins. Citrullinated synovial… (More)
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Highly Cited
2005
Highly Cited
2005
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.
Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in… (More)
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Highly Cited
2003
Highly Cited
2003
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic… (More)
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Highly Cited
2003
Highly Cited
2003
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause… (More)
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Highly Cited
2000
Highly Cited
2000
ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease
Dent's disease is an X-linked disorder associated with the urinary loss of low-molecular-weight proteins, phosphate and calcium… (More)
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Highly Cited
2000
Highly Cited
2000
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced…
Cytochrome c (cyt. c) is a proapoptotic factor that binds preferentially to cardiolipin (CL), a mitochondrial lipid, but not to… (More)
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Highly Cited
1998
Highly Cited
1998
Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule.
Mutations in the gene encoding the thiazide-sensitive Na+-Cl- cotransporter (NCC) of the distal convoluted tubule cause Gitelman… (More)
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Highly Cited
1996
Highly Cited
1996
Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.
We report the cloning, sequence analysis, tissue distribution, and functional expression of the K-Cl cotransport protein, KCC1… (More)
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Highly Cited
1990
Highly Cited
1990
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer.
We have used retrovirus-mediated gene transfer to demonstrate complementation of the cystic fibrosis (CF) defect in vitro… (More)
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