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Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population.
It is suggested that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population. Expand
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.
- A. Ichihara, M. Hayashi, +11 authors T. Saruta
- Chemistry, Medicine
- The Journal of clinical investigation
- 15 October 2004
It is proposed that the nonproteolytic activation of prorenin may be a significant mechanism of diabetic nephropathy and the mechanism and substances causing non Prorenin activation may serve as important therapeutic targets for the prevention of diabetic organ damage. Expand
Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy
The possibility that aldosterone blockade may represent optimal therapy for patients with early diabetic nephropathy who show ald testosterone escape during ACE inhibitor treatment and who no longer show maximal antiproteinuric effects of ACE inhibition is suggested. Expand
A New Member of the HCO 3 − Transporter Superfamily Is an Apical Anion Exchanger of β-Intercalated Cells in the Kidney*
- H. Tsuganezawa, K. Kobayashi, +12 authors T. Saruta
- Biology, Medicine
- The Journal of Biological Chemistry
- 16 March 2001
It is concluded that the newly cloned transporter is an apical anion exchanger of the β-intercalated cells, whereas the data do not exclude the possibility that there may be another form of an ion exchanger in these cells. Expand
Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune‐mediated demyelination
Inhibition of apoptosis in OLGs by p35 expression alleviated the severity of the neurological manifestations observed in autoimmune demyelinating diseases. Expand
Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly: Valsartan in Elderly Isolated Systolic Hypertension Study
Blood pressure targets of <140 mm Hg are safely achievable in relatively healthy patients ≥70 years of age with isolated systolic hypertension, although this trial was underpowered to definitively determine whether strict control was superior to less stringent blood pressure targets. Expand
Correlation between serum resistin level and adiposity in obese individuals.
Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance. Expand
Ca2+ channel subtypes and pharmacology in the kidney.
- K. Hayashi, S. Wakino, N. Sugano, Y. Ozawa, K. Homma, T. Saruta
- Chemistry, Medicine
- Circulation research
- 16 February 2007
Collectively, the kidney is endowed with a variety of Ca(2+) channel subtypes, and the inhibition of these channels by their specific CCBs leads to variable impact on renal microcirculation. Expand
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese.
- T. Yanagawa, M. Taniyama, +4 authors T. Saruta
- Biology, Medicine
- Thyroid : official journal of the American…
- 1 December 1997
It is shown that the CTLA4 gene could be one of the non-HLA linked susceptibility genes for GD and showed that CTLA-4 association with GD may be influenced by the racial composition of the population, it is important to study it in other ethnic groups. Expand
Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population.
- Yukihiro Yamamoto, H. Hirose, I. Saito, K. Nishikai, T. Saruta
- The Journal of clinical endocrinology and…
The findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight. Expand