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Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
MAINTENANCE of a stable internal environment within complex organisms requires specialized cells that sense changes in the extracellular concentration of specific ions (such as Ca2+). Although the… Expand
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.
- G. Gamba
- Biology, Medicine
- Physiological reviews
- 1 April 2005
Electroneutral cation-Cl(-) cotransporters compose a family of solute carriers in which cation (Na(+) or K(+)) movement through the plasma membrane is always accompanied by Cl(-) in a 1:1… Expand
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
- G. Gamba, A. Miyanoshita, +4 authors S. Hebert
- Chemistry, Medicine
- The Journal of biological chemistry
- 1 July 1994
Electrically silent Na(+)-(K+)-Cl- transporter systems are present in a wide variety of cells and serve diverse physiological functions. In chloride secretory and absorbing epithelia, these… Expand
Roles of the cation–chloride cotransporters in neurological disease
In the nervous system, the intracellular chloride concentration ([Cl−]i) determines the strength and polarity of γ-aminobutyric acid (GABA)-mediated neurotransmission. [Cl−]i is determined, in part,… Expand
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4
- F. H. Wilson, K. Kahle, +6 authors R. Lifton
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 6 January 2003
Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause pseudohypoaldosteronism type II (PHAII), a Mendelian disease featuring hypertension,… Expand
Cloning and Characterization of KCC3 and KCC4, New Members of the Cation-Chloride Cotransporter Gene Family*
- D. Mount, A. Mercado, +4 authors G. Gamba
- Biology, Medicine
- The Journal of Biological Chemistry
- 4 June 1999
The K+-Cl−cotransporters (KCCs) belong to the gene family of electroneutral cation-chloride cotransporters, which also includes two bumetanide-sensitive Na+-K+-2Cl−cotransporters and a… Expand
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases
- José Ponce-Coria, P. San-Cristobal, +11 authors G. Gamba
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 June 2008
The Na+:K+:2Cl− cotransporter (NKCC2) is the target of loop diuretics and is mutated in Bartter's syndrome, a heterogeneous autosomal recessive disease that impairs salt reabsorption in the kidney's… Expand
Activation of the renal Na+:Cl− cotransporter by angiotensin II is a WNK4-dependent process
- María Castañeda-Bueno, L. G. Cervantes-Pérez, +7 authors G. Gamba
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 May 2012
Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4… Expand
Identification and functional characterization of cation-chloride cotransporters in plants.
- J. M. Colmenero-Flores, Germán Martínez, +4 authors M. Talón
- Biology, Medicine
- The Plant journal : for cell and molecular…
- 21 March 2007
Chloride (Cl(-)) is an essential nutrient and one of the most abundant inorganic anions in plant tissues. We have cloned an Arabidopsis thaliana cDNA encoding for a member of the cation-Cl(-)… Expand
Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.
- G. Gamba, S. Saltzberg, +5 authors S. Hebert
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1993
Electroneutral Na+:Cl- cotransport systems are involved in a number of important physiological processes including salt absorption and secretion by epithelia and cell volume regulation. One group of… Expand
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