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Sodium-Potassium-Chloride Symporters

Known as: Na K Cl Symporter, Cotransporter, NaCl-KCl, Na K Cl Transporter 
A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process… 
National Institutes of Health

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Related topics

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Bartter DiseaseIn BloodProcess of secretionagonists

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NKCC Ncc69 protein, Drosophila

Papers overview

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Highly Cited
2003
Highly Cited
2003
KCl Cotransport Is an Important Modulator of Human Cervical Cancer Growth and Invasion*
Cervical cancer is a major world health problem for women, but the pathophysiology of this disease has received scant attention… 
Highly Cited
2003
Highly Cited
2003
Aberrant Chloride Transport Contributes to Anoxic/Ischemic White Matter Injury
Rundown of ionic gradients is a central feature of white matter anoxic injury; however, little is known about the contribution of… 
2003
2003
Specificity of Classical and Putative Cl- Transport Inhibitors on Membrane Transport Pathways in Human Erythrocytes
The majority of anion transport inhibitors tend to be non-specific. This is problematic from a research point of view as caution… 
Highly Cited
2000
Highly Cited
2000
Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue.
K-Cl cotransporters (KCC) play fundamental roles in ionic and osmotic homeostasis. To date, four mammalian KCC genes have been… 
Highly Cited
1998
Highly Cited
1998
Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans.
We isolated and characterized the cDNAs for the human, pig, and Caenorhabditis elegansK-Cl cotransporters. The pig and human… 
Highly Cited
1998
Highly Cited
1998
Stimulation of Na+-K+-2Cl-cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Na+-K+-2Cl-cotransporters are important in renal salt reabsorption and in salt secretion by epithelia. They are also essential in… 
Highly Cited
1991
Highly Cited
1991
Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways.
Furosemide, a loop diuretic, is known to inhibit the response to a variety of indirect bronchial challenges in humans but does… 
Highly Cited
1984
Highly Cited
1984
The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction
The electrophysiological properties of the dorsal and ventral canine lingual epithelium are studied in vitro. The dorsal… 
Highly Cited
1983
Highly Cited
1983
Basolateral KCl co-transport in a NaCl-absorbing epithelium
In NaCl–absorbing epithelia such as proximal renal tubule, small intestine and gallbladder, Na+-dependent Cl− entry across the… 
Highly Cited
1981
Highly Cited
1981
Mg/KCl-ATPase of plant plasma membranes is an electrogenic pump.
The function of the Mg(2+)-requiring KCl-stimulated ATPase (ATP phosphohydrolase, EC 3.6.1.3) of higher plants in active ion… 
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