Sodium-Potassium-Chloride Symporters

Known as: Na K Cl Symporter, Cotransporter, NaCl-KCl, Na K Cl Transporter 
A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process… (More)
National Institutes of Health

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NKCC Ncc69 protein, Drosophila

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Highly Cited
2009
Highly Cited
2009
Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity
Modulation of intracellular chloride concentration ([Cl(-)](i)) plays a fundamental role in cell volume regulation and neuronal… (More)
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Highly Cited
2008
Highly Cited
2008
Microbial life at high salt concentrations: phylogenetic and metabolic diversity
Halophiles are found in all three domains of life. Within the Bacteria we know halophiles within the phyla Cyanobacteria… (More)
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Highly Cited
2003
Highly Cited
2003
WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
Pseudohypoaldosteronism type II (PHAII) is an autosomal dominant disorder of hyperkalemia and hypertension. Mutations in two… (More)
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Highly Cited
2003
Highly Cited
2003
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause… (More)
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Highly Cited
2003
Highly Cited
2003
Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein.
Na-K-Cl cotransporter (NKCC2)-mediated sodium chloride reabsorption in the thick ascending limb is stimulated by the antidiuretic… (More)
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Highly Cited
2002
Highly Cited
2002
Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene.
Four genes encode electroneutral, Na+-independent, K-Cl cotransporters. KCC2, is exclusively expressed in neurons where it is… (More)
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Highly Cited
2002
Highly Cited
2002
Upregulation of renal BSC1 and TSC in prenatally programmed hypertension.
Prenatal factors, especially intrauterine growth retardation, have been shown to correlate with the risk of essential… (More)
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Highly Cited
1998
Highly Cited
1998
The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein.
Although the collecting duct is regarded as the primary site at which mineralocorticoids regulate renal sodium transport in the… (More)
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Review
1998
Review
1998
The Na-K-Cl cotransporters.
The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of a wide variety of… (More)
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Highly Cited
1994
Highly Cited
1994
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
Electrically silent Na(+)-(K+)-Cl- transporter systems are present in a wide variety of cells and serve diverse physiological… (More)
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