Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans.

  title={Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans.},
  author={E. J. Holtzman and S. Kumar and C. A. Faaland and F. Warner and P. Logue and S. Erickson and G. Ricken and J. Waldman and P. Dunham},
  journal={American journal of physiology. Renal physiology},
  volume={275 4},
  • E. J. Holtzman, S. Kumar, +7 authors P. Dunham
  • Published 1998
  • Biology, Medicine
  • American journal of physiology. Renal physiology
  • We isolated and characterized the cDNAs for the human, pig, and Caenorhabditis elegansK-Cl cotransporters. The pig and human homologs are 94% identical and contain 1,085 and 1,086 amino acids, respectively. The deduced protein of the C. elegans K-Cl cotransporter clone (CE-KCC1) contains 1,003 amino acids. The mammalian K-Cl cotransporters share ∼45% similarity with CE-KCC1. Hydropathy analyses of the three clones indicate typical KCC topology patterns with 12 transmembrane segments, large… CONTINUE READING
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