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Membrane mechanisms and intracellular signalling in cell volume regulation.
Recent work on selected aspects of the cellular and molecular physiology of cell volume regulation is reviewed. First, the physiological significance of the regulation of cell volume is discussed.Expand
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Active Cation Transport and Ouabain Binding in High Potassium and Low Potassium Red Blood Cells of Sheep
Red cells from high K sheep contained 82 mM K/liter cells and had a pump flux of 0.86 mM K/liter cells x hr; similarly, LK cells had 16.5 mM K/liter cells and a pump flux of 0.12 mM K/liter cells xExpand
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Passive potassium transport in low potassium sheep red cells: dependence upon cell volume and chloride.
The major pathway of passive K influx (ouabain‐insensitive) was characterized in low‐K type (LK) red cells of sheep. 1. Passive K transport in these cells was highly sensitive to variations in cellExpand
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Membrane-bound ATP fuels the Na/K pump. Studies on membrane-bound glycolytic enzymes on inside-out vesicles from human red cell membranes
ATP stimulates Na transport into inside-out vesicles (IOVs) made from human red cell membranes; strophanthidin inhibits the ATP-stimulated transport. The substrates for glyceraldehyde-3-phosphateExpand
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Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.
We isolated and characterized a novel K-Cl cotransporter, KCC3, from human placenta. The deduced protein contains 1,150 amino acids. KCC3 shares 75-76% identity at the amino acid level with human,Expand
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Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes.
  • I. Bize, P. Dunham
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 March 1994
K-Cl cotransport can participate in volume regulation in a number of cell types. Swelling activation of K-Cl cotransport in sheep erythrocytes proceeds by a two-step process, A<-->B<-->C (Dunham etExpand
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Swelling activation of K-Cl cotransport in LK sheep erythrocytes: a three-state process
K-Cl cotransport in LK sheep erythrocytes is activated by osmotic swelling and inhibited by shrinkage. The mechanism by which changes in cell volume are transduced into changes in transport wasExpand
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Effects of urea on K-Cl cotransport in sheep red blood cells: evidence for two signals of swelling.
  • P. Dunham
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 April 1995
The activation proceeds with a delay, like activation by swelling. Swelling of cells in urea activates K uptake further, but with no delay. Inactivation after removal of urea also proceeds withoutExpand
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Characterization of the endogenous Na(+)-K(+)-2Cl- cotransporter in Xenopus oocytes.
Over time, Xenopus laevis changed from producing stage V and VI oocytes with little native Na(+)-K(+)-2Cl- cotransport activity to those with substantial activity. In oocytes with high endogenousExpand
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Chloride-activated passive potassium transport in human erythrocytes.
Passive K+ transport in human erythrocytes (defined as ouabain-insensitive transport) was inhibited 70% by replacement of Cl- by several permeant monovalent anions. The Vmax of Cl--dependent K+Expand
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