Small Molecule

Known as: Small molecules 
A molecule with a low molecular weight that is not determined by a genome sequence.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Molecular Biologymolecular size
Nanotechnologychemical genetics

Papers overview

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Review
2017
Review
2017
Acute lymphoblastic leukemia: a comprehensive review and 2017 update
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per… (More)
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Review
2017
Review
2017
Drug candidates in clinical trials for Alzheimer’s disease
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with… (More)
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Highly Cited
2008
Highly Cited
2008
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4… (More)
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Highly Cited
2007
Highly Cited
2007
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2… (More)
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Highly Cited
2005
Highly Cited
2005
A small molecule–kinase interaction map for clinical kinase inhibitors
Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase… (More)
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Highly Cited
2004
Highly Cited
2004
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
The signaling pathways mediated by Rho family GTPases have been implicated in many aspects of cell biology. The specificity of… (More)
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Review
2004
Review
2004
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Protein–protein interactions have a key role in most biological processes, and offer attractive opportunities for therapeutic… (More)
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Highly Cited
2003
Highly Cited
2003
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.
Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four… (More)
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Highly Cited
2002
Highly Cited
2002
Small molecule modulation of Smoothened activity.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic… (More)
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Highly Cited
2001
Highly Cited
2001
A Second Generation Force Field for the Simulation of Proteins , Nucleic Acids , and Organic Molecules
We present the derivation of a new molecular mechanical force field for simulating the structures, conformational energies, and… (More)
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