chemical genetics

 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Biophysical signaling is required for both embryonic polarity and regenerative outgrowth. Exploiting endogenous ion transport for… (More)
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Review
2010
Review
2010
The success of the genomics revolution to construct a genetic architecture of a variety of model organisms has placed functional… (More)
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Highly Cited
2007
Highly Cited
2007
Polo-like kinases (Plks) play crucial roles in mitosis and cell division. Whereas lower eukaryotes typically contain a single Plk… (More)
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Highly Cited
2007
Highly Cited
2007
Cell division is controlled by cyclin-dependent kinases (CDKs). In metazoans, S phase onset coincides with activation of Cdk2… (More)
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Highly Cited
2007
Highly Cited
2007
Identifying the molecular pathways that are required for regeneration remains one of the great challenges of regenerative… (More)
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Highly Cited
2005
Highly Cited
2005
A chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs… (More)
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Highly Cited
2004
Highly Cited
2004
The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment… (More)
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2003
2003
An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule… (More)
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Review
2003
Review
2003
Forward chemical genetics is a new method to systematize the discovery and use of small molecules as tools for basic biological… (More)
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Review
2000
Review
2000
New methods enable the identification of compounds that both induce a specific cellular state and lead to identification of… (More)
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