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Skp2 Proteins

Known as: SKP2, p45, S-Phase Kinase-Associated Protein 2, p45 SKP2 
S-phase kinase-associated protein 2 (424 aa, ~48 kDa) is encoded by the human SKP2 gene. This protein is involved in the regulation of protein… 
National Institutes of Health

Related topics

Related topics

14 relations
Cell CycleCell Cycle ControlE2F1 Degradation PathwayG1 to S Transition Process

Broader (1)

S-Phase Kinase-Associated Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients.
BACKGROUND Ovarian cancer is the most common gynecological malignancy and constitutes the fifth leading cause of female cancer… 
2011
2011
Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer.
The effect of androgens on the prevention or promotion of cell cycle progression in ovarian and breast cancer is controversial… 
2010
2010
Overexpression of PPARγ can down-regulate Skp2 expression in MDA-MB-231 breast tumor cells
Skp2 is frequent amplified and overexpressed in breast cancer, making it a potential molecular target for cancer therapy. The… 
2008
2008
S‐phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B‐cell lymphoma
S‐phase kinase protein 2 (SKP2), an F‐box protein, targets cell‐cycle regulators including cycle‐dependent kinase inhibitor… 
2007
2007
Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms.
2007
2007
Regulation of SCFSKP2 Ubiquitin E3 Ligase Assembly and p27KIP1 Proteolysis by the PTEN Pathway and Cyclin D1
The PTEN tumor suppressor functions as a phosphatase of phosphatidylinositol 3,4,5-trisphosphate (PIP3) and negatively regulates… 
2005
2005
Expression of Skp2 and p27KIP1 in naevi and malignant melanoma of the skin and its relation to clinical outcome.
Skp2 (S-phase kinase associated protein 2) controls progression from G- to S-phase by promoting the proteolysis of the cyclin… 
2004
2004
The Expression of the F-Box Protein Skp2 is Negatively Associated with p27 Expression in Human Pituitary Tumors
The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development, and has been implicated in… 
Highly Cited
2003
Highly Cited
2003
Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.
Treatment of cancer cells with 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] or its analogs induces growth arrest and expression of… 
2002
2002
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers
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