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Skp2 Proteins

Known as: SKP2, p45, S-Phase Kinase-Associated Protein 2, p45 SKP2 
S-phase kinase-associated protein 2 (424 aa, ~48 kDa) is encoded by the human SKP2 gene. This protein is involved in the regulation of protein… 
National Institutes of Health

Related topics

Related topics

14 relations
Cell CycleCell Cycle ControlE2F1 Degradation PathwayG1 to S Transition Process

Broader (1)

S-Phase Kinase-Associated Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2
miR-186 has been demonstrated to have a significant role as a tumor suppressor in many types of cancers. Nevertheless, its… 
2010
2010
A Panel of Sputum-Based Genomic Marker for Early Detection of Lung Cancer
Non–small cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. We… 
Highly Cited
2009
Highly Cited
2009
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and… 
2007
2007
Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms.
Highly Cited
2006
Highly Cited
2006
Prognostic impact of Skp2 and p27 in human breast cancer
SummaryPurposeThe cell cycle is controlled by cyclin-dependent kinases and one of the key players is the cyclin-dependent kinase… 
Review
2006
Review
2006
Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/p25 and CDK2/Cyclin A Dynamics*
A detailed analysis is presented of the dynamics of human CDK5 in complexes with the protein activator p25 and the purine-like… 
Highly Cited
2006
Highly Cited
2006
Downregulation of the KIP family members p27KIP1 and p57KIP2 by SKP2 and the role of methylation in p57KIP2 inactivation in nonsmall cell lung cancer
Knowing the status of molecules involved in cell cycle control in cancer is vital for therapeutic approaches aiming at their… 
Highly Cited
2003
Highly Cited
2003
Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer.
PURPOSE Prostate carcinomas show a low level of the cell cycle inhibitor p27, which correlates with tumor aggressiveness. In… 
Highly Cited
2003
Highly Cited
2003
Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.
Treatment of cancer cells with 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] or its analogs induces growth arrest and expression of… 
Highly Cited
1998
Highly Cited
1998
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
The budding yeast gene product, CDC53p, forms E3-like SCF complexes with SKP1 and F-box-containing proteins to mediate the… 
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