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Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
BACKGROUND The molecular cause of inflammatory bowel disease is largely unknown. METHODS We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelatedExpand
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HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing
Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer in a large multicentric trial (ToGA study). Subgroup analysisExpand
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Impact of patatin‐like phospholipase‐3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome‐wide association study identified a genetic variantExpand
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Quantitative assessment of promoter hypermethylation during breast cancer development.
The aberrant methylation of cytosine residues in the promoter region of growth regulatory genes is now widely recognized as an additional mechanism for gene inactivation in cancer cells. In thisExpand
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Incidence of polyomavirus-nephropathy in renal allografts: influence of modern immunosuppressive drugs.
BACKGROUND In recent years an increasing number of cases with polyomavirus (PV)-nephropathy after renal transplantation were reported from several transplant centres. New, highly potentExpand
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Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
BACKGROUND & AIMS Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD).Expand
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Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies.
The archives of departments of pathology represent a unique source of morphologically defined biopsies derived from normal and pathologically altered tissues for which extensive clinical data areExpand
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Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer
MicroRNAs (miRNAs) represent a new class of small non‐coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been describedExpand
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Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American
HER2 is an important tumour marker in breast cancer. However, there is controversy regarding which method reliably measures HER2 status. This study evaluates the concordance between HER2 geneExpand
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Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation.
Among the more than 100 published cases of Philadelphia chromosome–positive chronic myelogenous leukemia (Ph+ CML) investigated for the 1849G > T mutation of the Janus kinase 2 (JAK2V617F),[1][1]noExpand
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