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Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
Tumor contains small population of cancer stem cells (CSC) that are responsible for its maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and therapeutic strategies for… Expand
Molecular and cellular mechanisms of pulmonary fibrosis
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered… Expand
Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers
Adenocarcinoma is the most common type of lung cancer, the leading cause of cancer deaths in the world. Early detection is the key to improve the survival of lung adenocarcinoma patients. We have… Expand
Plasma microRNAs as potential biomarkers for non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death. Developing minimally invasive techniques that can diagnose NSCLC, particularly at an early stage, may improve its… Expand
Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers
Squamous cell carcinoma is a common form of lung cancer, the leading cause of cancer deaths in the world. Identifying early stage lung squamous cell carcinoma patients who would benefit most from… Expand
Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer.
UNLABELLED Analysis of molecular genetic markers in biological fluids has been proposed as a useful tool for cancer diagnosis. MicroRNAs (miRNAs) are small regulatory RNAs that are frequently… Expand
Interleukin-33 potentiates bleomycin-induced lung injury.
- I. G. Luzina, P. Kopach, +6 authors S. Atamas
- Biology, Medicine
- American journal of respiratory cell and…
- 1 December 2013
The mechanisms of interstitial lung disease (ILD) remain incompletely understood, although recent observations have suggested an important contribution by IL-33. Substantial elevations in IL-33… Expand
Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers
BackgroundMaking a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used… Expand
Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
- A. Mozaffarian, A. W. Brewer, +4 authors H. Arnett
- Biology, Medicine
- The Journal of Immunology
- 15 November 2008
Oncostatin M (OSM), an IL-6 family cytokine, has been implicated in a number of biological processes including the induction of inflammation and the modulation of extracellular matrix. In this study,… Expand
Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target.
A functional genomic approach integrating microarray and proteomic analyses done in our laboratory has identified 14-3-3zeta as a putative oncogene whose activation was common and driven by its… Expand