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Sivelestat Sodium

National Institutes of Health

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sivelestat

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2014
2014
Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.
2013
2013
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Highly Cited
2012
Highly Cited
2012
Recent advancements of total aortic arch replacement.
2009
2009
Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
Prevention of paraplegia remains an important issue in repair of descending thoracic and thoracoabdominal aneurysms. Therefore… 
2008
2008
Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.
2007
2007
EFFECTS OF SPECIFIC NEUTROPHIL ELASTASE INHIBITOR, SIVELESTAT SODIUM HYDRATE, IN MURINE MODEL OF SEVERE PNEUMOCOCCAL PNEUMONIA
An excessive amount of neutrophil elastase (NE) released from neutrophils accumulated in the lung can cause tissue damage… 
2006
2006
PRETREATMENT OF SIVELESTAT SODIUM HYDRATE IMPROVES THE LUNG MICROCIRCULATION AND ALVEOLAR DAMAGE IN LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INFLAMMATION IN HAMSTERS
ABSTRACT Damage to the lung microcirculation and alveoli caused by activated leukocytes is known to play an important role in the… 
2006
2006
Effect of a Polymorphonuclear Elastase Inhibitor (Sivelestat Sodium) on Acute Lung Injury After Cardiopulmonary Bypass: Findings of a Double-Blind Randomized Study
PurposeWe evaluated the effect of sivelestat sodium (SiV), a novel synthesized polymorphonuclear (PMN) elastase inhibitor, on… 
Highly Cited
2004
Highly Cited
2004
Relationship between neutrophil elastase and acute lung injury in humans.
Highly Cited
2000
Highly Cited
2000
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
To define the role of neutrophil elastase (NE) in the progression of acute lung injury (ALI), we examined the effects of post… 
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