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Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine
Findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents. Expand
Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala
The present data constitute the first evidence that chronic pain has an anxiogenic effect in mice and may be associated with changes in opioidergic function in the amygdala. Expand
Direct evidence for the involvement of brain‐derived neurotrophic factor in the development of a neuropathic pain‐like state in mice
It is demonstrated here for the first time that the increase in intracellular Ca2+ concentration by application of BDNF in cultured mouse spinal neurons was abolished by pre‐treatment with either K‐252a or Ro‐32‐0432. Expand
Implication of protein kinase C in the orexin‐induced elevation of extracellular dopamine levels and its rewarding effect
In the present study, we investigated the role of orexinergic systems in the activation of midbrain dopamine neurons. In an in vitro study, exposure to either orexin A or orexin B under superfusionExpand
Hyperalgesia induced by pituitary adenylate cyclase-activating polypeptide in the mouse spinal cord.
It is suggested that PACAP may be a sensory neurotransmitter involved in nociceptive signalling in the mouse spinal cord and produced licking at tail, paw and penis and intense grooming behaviors immediately after the i.t. injection. Expand
Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
It is proposed that endomorphin-1 produces antinociception by stimulating one type of mu-opioid receptor, whereas endomorphicin-2 initially stimulates different mu-OPioid receptors, which subsequently induce the release of dynorphins that act on kappa-opIOid receptors to produce antinOCiception. Expand
Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse.
It is suggested that protein kinase C, but notprotein kinase A, plays an important role in the development of acute tolerance to the mu-opioid receptor agonist-induced antinociception. Expand
Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment
It is suggested that an enriched environment increases BDNF mRNA expression via sustained epigenetic modification in the mouse hippocampus via sustained methylases and demethylases in the hippocampus. Expand
Blockade of morphine reward through the activation of κ-opioid receptors in mice
Abstract The effects of systemic (s.c.) treatment with the κ-agonists U-50,488H and E-2078 (a stable dynorphin analog) on the morphine-induced place preference were examined in mice. Morphine (s.c.)Expand
Direct Evidence of Astrocytic Modulation in the Development of Rewarding Effects Induced by Drugs of Abuse
Direct evidence is provided that astrocytes may, at least in part, contribute to the synaptic plasticity induced by drugs of abuse during the development of rewarding effects induced by psychostimulants and opioids. Expand