• Publications
  • Influence
In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
TLDR
The first successful in vivo transfer of NFκB decoy oligodeoxynucleotides to reduce the extent of myocardial infarction following reperfusion is reported, providing a new therapeutic strategy for myocardia infarctions. Expand
Hepatocyte growth factor gene therapy of liver cirrhosis in rats
TLDR
In a rat model of lethal liver cirrhosis produced by dimethylnitrosamine administrations, repeated transfections of the human HGF gene into skeletal muscles induced a high plasma level of human as well as enodogenous rat HGF, and tyrosine phosphorylation of the c–Met/HGF receptor suppressed the increase of transforming growth factor–β1 and produced the complete resolution of fibrosis in the cirrhotic liver. Expand
Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology.
TLDR
The results indicated that the prevascularized myoblast sheet constructs could induce functional anastomosis and provide a substantial advance for developing various types of three-dimensional tissues and contributes to regenerative medicine. Expand
Interleukin-6 derived from hypoxic myocytes promotes neutrophil-mediated reperfusion injury in myocardium.
TLDR
Interleukin-6 is produced from myocardium during ischemia and reperfusion in patients undergoing coronary bypass grafting and may be derived from hypoxic myocytes and play a role in neutrophil-mediated reperfusions injury in myocardia. Expand
Long-term results of the open stent-grafting technique for extended aortic arch disease.
TLDR
Long-term observation showed safety and good durability of the open stent-grafting technique for aortic arch disease, and this technique could be an attractive treatment option for aortsic arch aneurysm with distal extension and aortics dissection requiring aortIC arch replacement. Expand
Long-term outcomes after a variety of video-assisted thoracoscopic lobectomy approaches for clinical stage IA lung cancer: a multi-institutional study.
TLDR
V VATS lobectomy, a safe procedure with earlier return to normal activities, can be regarded as an acceptable cancer operation for the patients with peripheral non-small cell lung cancer less than or equal to 2 cm in diameter with the same long-term survivals as open surgery. Expand
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension
TLDR
It is suggested that IL-21 promotes PAH in association with M2 macrophage polarization, downstream of IL-6-signaling, through the polarization of primary alveolar macrophages toward the M2 phenotype. Expand
Leukocyte depletion attenuates reperfusion injury in patients with left ventricular hypertrophy.
TLDR
It is demonstrated that leukocyte-depleted reperfusion is potentially beneficial as an adjunct to terminal cardioplegia during cardiac surgery to attenuate reperfusions injury in patients with left ventricular hypertrophy. Expand
In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding.
TLDR
This study indicated that this novel tissue-engineered vascular graft promoted in situ tissue regeneration and did not require ex vivo cell seeding, thereby conferring better patency on small-caliber vascular prostheses. Expand
HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins.
TLDR
The results suggest that the anti-inflammatory effects of HDL on macrophages might be due to suppression of the conversion of progranulin into proinflammatory granulins by forming a complex. Expand
...
1
2
3
4
5
...