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Serotonin 5-HT1 Receptor Antagonists

Known as: 5-HT1 Antagonist, 5 HT1 Antagonist, Antagonists, 5-HT1 
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under… Expand
National Institutes of Health

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In Bloodaspects of radiation effectschemical synthesisstandards characteristics

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MM 77Serotonin 5-HT1A Receptor AntagonistsSerotonin 5-HT1B-D Antagonistsisamoltane
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Papers overview

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2005
2005
Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat
The core temperature of male Wistar rats was measured after local application of 5-HT (10 µg) or 8-OH-DPAT (5 µg) into the dorsal… Expand
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2001
2001
A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization.
Little is currently known regarding the electrophysiological response elicited by 5-hydroxytryptamine-7 (5-HT(7)) receptor… Expand
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Highly Cited
1998
Highly Cited
1998
SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.
1. Human 5-HT1B (h5-HT1B) and human 5-HT1D (h5-HT1D) receptors show remarkably similar pharmacology with few compounds… Expand
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1995
1995
The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1BD receptor antagonists
Serotonin (5-HT) efflux in slices of rat dorsal raphe nucleus (DRN) was evoked by pseudo one pulse electrical stimulation (20… Expand
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Highly Cited
1993
Highly Cited
1993
Serotonin-facilitated dopamine release in vivo: pharmacological characterization.
The receptor specificity of serotonin (5-HT) agonist-induced facilitation of dopamine (DA) release was assessed by using in vivo… Expand
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1993
1993
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of…
The second messenger coupling of cloned human 5-hydroxytryptamine (5-HT)1D alpha and 5-HT1D beta receptors stably expressed in… Expand
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Highly Cited
1992
Highly Cited
1992
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
1. The role of serotonin (5-HT) and excitatory amino-acids (EAAs) in the activation of the neural networks (i.e. the central… Expand
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Highly Cited
1991
Highly Cited
1991
Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis.
Using microdialysis, changes in extraneuronal levels of dopamine (DA), and the metabolites of DA and serotonin (5-HT), were… Expand
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1986
1986
Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum.
The release of endogenous glutamate (GLU) elicited by depolarization of rat cerebellum synaptosomes was inhibited potently (pEC30… Expand
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Highly Cited
1985
Highly Cited
1985
A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors.
Radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-HT) binding subtypes: 5-HT2, 5-HT1A and… Expand
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