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Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: A comparison between the effects produced by pre- and post-synaptic inhibition of
TLDR
Using exploratory locomotor activity as an index of limbic forebrain DA functions and treadmill locomotion and catalepsy as indices of extrapyramidal DA functions, the DA autoreceptor agonists, in contrast to the postsynaptic antagonist, show a difference in the doses required to produce these effects. Expand
Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat
TLDR
Investigation of the organization of afferent and efferent connections of the interpeduncular nucleus (IP) has been examined in correlation with its subnuclear parcellation by using anterograde and retrograde tracing techniques and Immunohistochemical techniques showed cell bodies and fibers and terminals immunoreactive for substance P, leuenkephalin, metenkePhalin, or serotonin to be differentially distributed over the different IP subnuclei. Expand
Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour.
TLDR
The results would suggest that at least some of the 5-HT1A receptors involved in the facilitation of male sexual behaviour are located postsynaptically in limbic brain areas that regulate maleSexual behaviour. Expand
Suppression of conditioned avoidance behavior by the local application of (−)sulpiride into the ventral, but not the dorsal, striatum of the rat
TLDR
It is concluded that the performance of conditioned avoidance behavior in the rat is critically dependent on an intact dopaminergic neurotransmission in the nucleus accumbens or adjacent areas of the ventral striatum. Expand
Effects of a new type of 5-HT receptor agonist on male rat sexual behavior
TLDR
It was found that both drugs reduce the number of intromissions preceding ejaculation and shorten the ejaculation latency and sexual behavior was partly or completely restored in castrated male rats after injection with 8-OMe- DPAT or 8-OH-DPAT. Expand
Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT1A and 5‐HT1B receptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and
TLDR
The present results demonstrate opposite effects, facilitation and inhibition, of male rat ejaculatory behaviour by stimulation of 5‐HT1A and 5‐ HT1B receptors, respectively, suggesting that the SSRI‐induced inhibition of male ejaculatory dysfunction is due to 5-HT1B receptor stimulation. Expand
Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms.
TLDR
The present results provide evidence for functional interactions between 5-HT1A and 5- HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 4-HT2A/C receptors in the mediation of DOI-induced hyperthermia. Expand
Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behaviour and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol
TLDR
Raclopride is more potent than preclamol in suppressing treadmill locomotion, conditioned avoidance behaviour and catalepsy, indicating less propensity to produce severe extrapyramidal side effects. Expand
High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
TLDR
A spectrum of effects caused by oxytocin was similar to that of midazolam but different from that induced by raclopride, and the behavior gradually returned to normal within 24 h. Expand
Behavioral and biochemical effects of the dopamine D3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat.
TLDR
It appears that the dopamine D3 receptor-preferring ligand, 7-OH-DPAT, displays the profile of a dopamine D2 receptor agonist, pre- and postsynaptically. Expand
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