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Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced
TLDR
The results indicate distinct, and in some cases opposite, effects of a 5-HT2A compared with a 5,HT2C receptor antagonist on various cocaine-mediated behavioral effects. Expand
Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.
TLDR
The present series of studies suggest that, in addition to reducing food intake, 5-HT(2C) receptor agonists reduce cocaine-reinforced behavior, which would be consistent with electrophysiological and biochemical evidence suggesting an important modulatory influence of 5- HT( 2C) receptors on mesolimbic dopamine function. Expand
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*
TLDR
In vivo studies show that inhibition of γ-secretase has the expected benefit of reducing Aβ in a murine model of Alzheimer disease but has potentially undesirable biological effects as well, most likely because of the inhibition of Notch processing. Expand
The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism
TLDR
The results suggest that 5-HT2A receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction, as well as attenuate the hyperlocomotion and stereotypy produced by dizocilpine. Expand
Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task
TLDR
The results suggest that alpha(7) receptors do not play a role in any of the behavioural effects of nicotine observed in the 5-CSRTT, whereas a high affinity site, perhaps alpha(4)beta(2), is more likely involved. Expand
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.
TLDR
In vivo studies show that inhibition of gamma-secretase has the expected benefit of reducing Abeta in a murine model of Alzheimer disease but has potentially undesirable biological effects as well, most likely because of the inhibition of Notch processing. Expand
Opposing effects of 5-HT2A and 5-HT2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test
TLDR
Serotonin exerts both excitatory and inhibitory influences on motor impulsivity via 5- HT2A and 5-HT2C receptors in both rats and mice. Expand
Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
TLDR
Results indicate a negligible role of alpha(7) receptors in nicotine-induced hyperlocomotion and reward in the rat, and support the view for an involvement of a member from the high-affinity nicotinic receptor subclass, possibly alpha(4)beta(2). Expand
Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration
Previously, we have shown that systemic administration of the 5-HT2C receptor agonist Ro60-0175 reduces cocaine-induced locomotor activity and cocaine self-administration. Ro60-0175 also alters theExpand
Serotonin and drug reward: focus on 5-HT2C receptors.
TLDR
Evidence that central 5-HT systems similarly modulate reward-related behaviours, particularly drug reward, is reviewed and what are believed to be strong emerging pharmacological and genetic evidence that many of these effects are mediated through 5- HT(2C) receptor signalling mechanisms are considered. Expand
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