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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
- C. Wahlestedt, P. Salmi, J. Wengel
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 9 May 2000
It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene.
Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms.
The present results provide evidence for functional interactions between 5-HT1A and 5- HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 4-HT2A/C receptors in the mediation of DOI-induced hyperthermia.
Behavioral and biochemical effects of the dopamine D3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat.
Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion
The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram
- L. Arborelius, G. Nomikos, T. Svensson
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 May 1996
The capacity of (S)-UH-301 to further increase the already elevated extracellular concentrations of 5-HT in brain in animals maintained on a chronic citalopram regimen, in which significant tolerance to the initial feedback inhibition of DRN-5-HT cells had developed, represents a novel finding.
Evidence for specific involvement of dopamine D1 and D2 receptors in the regulation of body temperature in the rat.
Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties
In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors 1 Presented in part at the `9th ECNP Congress', Amsterdam,…
Endocrine and behavioral traits in low-avoidance performing Sprague–Dawley rats
Endocrine and behavioral traits in low-avoidance Sprague-Dawley rats.
- K. Uvnäs-Moberg, E. Björkstrand, P. Salmi, C. Johansson, M. Åstrand, S. Ahlénius
- Biology, PsychologyRegulatory peptides
The evidence obtained here, and in other laboratories, suggests that the Stock B animals display hormonal changes indicative of a submissive-defensive reaction pattern, which is in all probability caused by emotional reactions when challenged with external stimuli requiring active responding.