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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
TLDR
It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene. Expand
Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms.
TLDR
The present results provide evidence for functional interactions between 5-HT1A and 5- HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 4-HT2A/C receptors in the mediation of DOI-induced hyperthermia. Expand
Behavioral and biochemical effects of the dopamine D3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat.
TLDR
It appears that the dopamine D3 receptor-preferring ligand, 7-OH-DPAT, displays the profile of a dopamine D2 receptor agonist, pre- and postsynaptically. Expand
Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion
TLDR
Whether there are differences between Flinders Sensitive Line rats, an animal model of depression, and controls, Flinders Resistant Line (FRL) in baseline brain NPY-LI concentrations is explored and effects of ECS on locomotion and brain neuropeptides, amphetamine effects on behavior are explored. Expand
The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram
TLDR
The capacity of (S)-UH-301 to further increase the already elevated extracellular concentrations of 5-HT in brain in animals maintained on a chronic citalopram regimen, in which significant tolerance to the initial feedback inhibition of DRN-5-HT cells had developed, represents a novel finding. Expand
Evidence for specific involvement of dopamine D1 and D2 receptors in the regulation of body temperature in the rat.
TLDR
Results suggest that both dopamine D1 and D2 receptors are specifically involved in the regulation of body temperature in the rat, and that both receptors are antagonized by pretreatment with a selective dopamine D2 receptor antagonist. Expand
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
TLDR
The consequences of MeHg toxicity during gestation and lactation can be reduced by adenosine A(1) and A(2A) receptor inactivation, either via their genetic deletion or by treatment with their antagonist caffeine. Expand
In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors 1 Presented in part at the `9th ECNP Congress', Amsterdam,
TLDR
It is concluded that S(-)-UH-301, but not WAY-100,635 or NAD-299, displays intrinsic efficacy at brain 5-HT1A and DA D2/3 receptors, whereas WAY- 100,635 behaves as a DA D 2/3 receptor antagonist. Expand
Endocrine and behavioral traits in low-avoidance performing Sprague–Dawley rats
TLDR
The evidence obtained here, and in other laboratories, suggests that the Stock B animals display hormonal changes indicative of a submissive-defensive reaction pattern, which is in all probability caused by emotional reactions when challenged with external stimuli requiring active responding. Expand
Endocrine and behavioral traits in low-avoidance Sprague-Dawley rats.
TLDR
The evidence obtained here, and in other laboratories, suggests that the Stock B animals display hormonal changes indicative of a submissive-defensive reaction pattern, which is in all probability caused by emotional reactions when challenged with external stimuli requiring active responding. Expand
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