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Selenoprotein P, human

Known as: SEPP1, SeP, Selenoprotein P 
Selenoprotein P (381 aa, ~43 kDa) is encoded by the human SEPP1 gene. This protein is involved in the modulation of selenium metabolism.
National Institutes of Health

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Related topics

6 relations
Extracellular SpaceLigand BindingPlasmaSEPP1 gene
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Broader (1)

Selenoprotein P

Papers overview

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2015
2015
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients… Expand
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Review
2015
Review
2015
Regulation of Selenium Metabolism and Transport.
Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells… Expand
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Review
2013
Review
2013
Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system.
The essential trace element selenium, as selenocysteine, is incorporated into antioxidant selenoproteins such as glutathione… Expand
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Highly Cited
2012
Highly Cited
2012
Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis*
Background: Sepp1 transports selenium, but its complete role in selenium homeostasis is not known. Results: Deletion of Sepp1 in… Expand
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Highly Cited
2011
Highly Cited
2011
Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation.
Oxidative stress and low-grade inflammation have been implicated in obesity and insulin resistance. As a selenium transporter… Expand
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Highly Cited
2010
Highly Cited
2010
Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine…
BACKGROUND The intake of selenium needed for optimal health has not been established. Selenoproteins perform the functions of… Expand
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Review
2009
Review
2009
Selenoprotein P-expression, functions, and roles in mammals.
Selenoprotein P (Sepp1) is a secreted protein that is made up of 2 domains. The larger N-terminal domain contains 1… Expand
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Highly Cited
2008
Highly Cited
2008
Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells*
Selenoprotein P (Sepp1) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain, and testis as a… Expand
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Highly Cited
2007
Highly Cited
2007
Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis*
Selenium is a micronutrient that is essential for the production of normal spermatozoa. The selenium-rich plasma protein… Expand
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Highly Cited
2007
Highly Cited
2007
The Selenium-rich C-terminal Domain of Mouse Selenoprotein P Is Necessary for the Supply of Selenium to Brain and Testis but Not for the Maintenance of Whole Body Selenium*
Selenoprotein P (Sepp1) has two domains with respect to selenium content: the N-terminal, selenium-poor domain and the C-terminal… Expand
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