Selenoprotein P, human

Known as: SEPP1, SeP, Selenoprotein P 
Selenoprotein P (381 aa, ~43 kDa) is encoded by the human SEPP1 gene. This protein is involved in the modulation of selenium metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
05101519792017

Related topics

Related topics

5 relations
Extracellular SpaceLigand BindingPlasmaSEPP1 gene

Broader (1)

Selenoprotein P

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Selenoprotein P, human
Plasma
Extracellular Space
Ligand Binding
Selenoprotein P
SEPP1 gene

Papers overview

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2014
2014
Effects of Dietary Selenium Deficiency on mRNA Levels of Twenty-One Selenoprotein Genes in the Liver of Layer Chicken
Selenium (Se) is an essential trace element in many life forms due to its occurrence as selenocysteine (Sec) residue in… (More)
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2012
2012
Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis.
BACKGROUND Sepp1 transports selenium, but its complete role in selenium homeostasis is not known. RESULTS Deletion of Sepp1 in… (More)
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2011
2011
Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation.
Oxidative stress and low-grade inflammation have been implicated in obesity and insulin resistance. As a selenium transporter… (More)
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2008
2008
Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.
Selenoprotein P (Sepp1) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain, and testis as a… (More)
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2008
2008
Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2.
Selenoprotein P (Sepp1) is involved in selenium homeostasis. Mice with a deletion of Sepp1, replacement of it by the shortened… (More)
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Highly Cited
2007
Highly Cited
2007
Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis.
Selenium is a micronutrient that is essential for the production of normal spermatozoa. The selenium-rich plasma protein… (More)
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2007
2007
All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium.
The brain and testis retain selenium better than other tissues during selenium deficiency. Studies of mice with selenoprotein P… (More)
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2007
2007
Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed.
Selenoprotein P (Sepp1) is a plasma and extracellular protein that is rich in selenium. Deletion of Sepp1 results in sharp… (More)
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2007
2007
The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium.
Selenoprotein P (Sepp1) has two domains with respect to selenium content: the N-terminal, selenium-poor domain and the C-terminal… (More)
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2006
2006
Altered hippocampus synaptic function in selenoprotein P deficient mice
Selenium is an essential micronutrient that function through selenoproteins. Selenium deficiency results in lower concentrations… (More)
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