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Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population
In a Japanese population, another risk variant in ABCG2, namely the Q126X nonfunctional mutation, confers an even higher risk associated with an increase in uric acid deposition in the blood and may cause gout in Asians, lending weight to previously reported GWAS. Expand
New prognostic factors and scoring system for patients with skeletal metastasis
This revised scoring system was able to predict the survival rates of patients with skeletal metastases more accurately than the previous system and may be useful for selecting an optimal treatment. Expand
Glomerular hyperfiltration in prediabetes and prehypertension.
- R. Okada, Y. Yasuda, K. Tsushita, K. Wakai, N. Hamajima, S. Matsuo
- Nephrology, dialysis, transplantation : official…
- 1 May 2012
The prevalence of glomerular hyperfiltration increased with increasing stages of prediabetes and prehypertension, and kidney function should be monitored in subjects with predi diabetes or prehyertension. Expand
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes
- H. Matsuo, Ken Yamamoto, +37 authors N. Shinomiya
- Annals of the rheumatic diseases
- 2 February 2015
It is demonstrated that the SNPs of ABCG2 and SLC2A9 were differentially associated with types of gout and clinical parameters underlying specific subtypes (renal underexcretion type and renal overload type) and the effect of the risk allele of each SNP on clinical parameters showed significant linear relationships. Expand
Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study.
The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. Expand
Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population.
- N. Hamajima, R. Okada, +10 authors M. Naito
- Biology, Medicine
- Molecular genetics and metabolism
- 1 August 2011
This study aimed to confirm the association of SLC2A9 (GLUT9) gene polymorphisms with serum uric acid (SUA) levels, and estimate the means of SUA according to the genotype, as well as OR of the genotypes. Expand
Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study
The functional promoter polymorphisms IL4 T-33C and IL6 C-572G, which are the only SNPs that affect the IL-4 and IL-6 levels in Japanese subjects, were associated with kidney function and CKD prevalence in a large Japanese population. Expand
Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population.
This was the first report on the interaction between LRP2 genotype and alcohol drinking for SUA and the association with rs2544390 was stronger among male drinkers. Expand
Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies
- Y. Hattori, M. Naito, +13 authors K. Wakai
- Toxicological sciences : an official journal of…
- 27 April 2016
MT2A A-5G is a promising target for evaluations of CKD and DM risks with possible involvement of low-dose chronic exposure to environmental pollutants. Expand
Multiple common and rare variants of ABCG2 cause gout
It is revealed that multiple common and rare variants of ABCG2 are independently associated with gout, which could support both the ‘Common Disease, Common Variant’ and ‘ common Disease, Multiple Rare variant’ hypotheses for the association betweenABCG2 and gout susceptibility. Expand