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Scrapie

Known as: Rida, Scrapie [Disease/Finding] 
A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by… 
National Institutes of Health

Related topics

Related topics

10 relations
In BloodMicrobiologicalPrPSc ProteinsPrion Diseases

Broader (1)

Spongiform encephalopathy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
Prions are usually quantified by bioassays based on intracerebral inoculation of mice that are slow, imprecise, and costly. We… 
Highly Cited
1999
Highly Cited
1999
Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
The immune system is central in the pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs) or 'prion… 
Highly Cited
1997
Highly Cited
1997
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.
The scrapie prion protein (PrPSc) is the major, and possibly the only, component of the infectious prion; it is generated from… 
Highly Cited
1993
Highly Cited
1993
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
The accumulation of an abnormal, protease-resistant form of the protein PrP (PrP-res) in hosts with scrapie and related… 
Highly Cited
1993
Highly Cited
1993
Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.
The infectious form of the scrapie amyloid (prion) precursor, PrPSc, is a host-derived protein and a component of the infectious… 
Highly Cited
1993
Highly Cited
1993
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
Highly Cited
1992
Highly Cited
1992
Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
The “modified host protein” model of scrapie proposes that the transmissible agent is composed of the degradation-resistant… 
Highly Cited
1991
Highly Cited
1991
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy.
A protease-resistant form of the protein PrP (PrP-res) accumulates in tissues of mammals infected with scrapie, Creutzfeldt-Jakob… 
Highly Cited
1989
Highly Cited
1989
Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein.
Prion proteins from humans and rodents contain two consensus sites for asparagine-linked glycosylation near their C-termini. The… 
Highly Cited
1982
Highly Cited
1982
Measurement of the scrapie agent using an incubation time interval assay
The titer of the scrapie agent was determined by measurements of time intervals from inoculation to onset of illness and from… 
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