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Scrapie

Known as: Rida, Scrapie [Disease/Finding] 
A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Prions are unconventional infectious agents responsible for transmissible spongiform encephalopathy (TSE) diseases. They are… Expand
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Highly Cited
2005
Highly Cited
2005
In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In… Expand
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Highly Cited
1996
Highly Cited
1996
The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc… Expand
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Highly Cited
1993
Highly Cited
1993
S.B. Prusiner proposed that the infectious agent of scraple, the prion, is PrPSc, a modified form of the normal host protein PrPC… Expand
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Highly Cited
1993
Highly Cited
1993
Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc… Expand
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Highly Cited
1987
Highly Cited
1987
The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought… Expand
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Highly Cited
1985
Highly Cited
1985
A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected… Expand
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Highly Cited
1985
Highly Cited
1985
We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged… Expand
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Highly Cited
1982
Highly Cited
1982
After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system… Expand
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Highly Cited
1982
Highly Cited
1982
Purification of prions from scrapie-infected hamster brain yielded a protein that was not found in a similar fraction from… Expand
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